Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers Else Müller-Schweinitzer, MD, Sandra.

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Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers Else Müller-Schweinitzer, MD, Sandra E. Müller, MSc, David C. Reineke, MD, Thomas Kern, MD, Thierry P. Carrel, MD, Friedrich S. Eckstein, MD, Martin T.R. Grapow, MD Journal of Vascular Surgery Volume 51, Issue 2, Pages 438-444 (February 2010) DOI: 10.1016/j.jvs.2009.09.040 Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 1 Cumulative concentration-response curves to endothelin-1 (ET-1) on arterial rings from smokers (SM, dashed line) and nonsmokers (NS, solid line). Contraction was significantly stronger in rings from (left) internal thoracic arteries (ITA; 32 SM, 38 NS) and (right) radial arteries (RA; 16 SM, 24 NS) from smokers than from nonsmokers (P < .05). Mean responses are expressed in g, and the vertical bars represent standard error of the mean. Journal of Vascular Surgery 2010 51, 438-444DOI: (10.1016/j.jvs.2009.09.040) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 2 Cumulative concentration-response curves to acetylcholine (ACH) on arterial rings taken from smokers (SM, dashed line) and nonsmokers (NS, solid line). Left, Relaxation of rings from the internal thoracic artery (ITA) from smokers was significantly stronger than in nonsmokers (20 SM, 22 NS, P = .041). Right, The opposite was true on radial artery (RA) rings; that is, the endothelium-dependent relaxation of RA from smokers was significantly attenuated (10 SM, 8 NS, P = .038). Mean responses are expressed in percentages of the potassium chloride-induced tone. The vertical bars represent standard error of the mean. Journal of Vascular Surgery 2010 51, 438-444DOI: (10.1016/j.jvs.2009.09.040) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 3 Representative fluorescent photomicrographs of an inverted human radial artery (RA) segment stained with 5-(&6)-chloromethyl-2′-7′-dichlorodihydro-fluorescein diacetate (DCDHF) during exposure to (left) 37°C and (right) 28°C. The horizontal bars indicate 100 μm. Journal of Vascular Surgery 2010 51, 438-444DOI: (10.1016/j.jvs.2009.09.040) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 4 Normalized changes of fluorescence intensities of 5-(&6)-chloromethyl-2′-7′-dichlorodihydro-fluorescein diacetate (DCDHF)-stained internal thoracic arteries (ITA) and radial arteries (RA) are shown during exposure to 37°C and 28°C. The bars represent standard error of the mean. For each column, n = 21 from five patients. Journal of Vascular Surgery 2010 51, 438-444DOI: (10.1016/j.jvs.2009.09.040) Copyright © 2010 Society for Vascular Surgery Terms and Conditions