Paraneoplastic glomerulopathies: New insights into an old entity

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Paraneoplastic glomerulopathies: New insights into an old entity Pierre M. Ronco Kidney International Volume 56, Issue 1, Pages 355-377 (July 1999) DOI: 10.1046/j.1523-1755.1999.00548.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Patient 1. (A) Light microscopy. Note discrete thickening of the glomerular capillary walls and mild podocyte hypertrophy (Masson trichrome; original magnification × 312). (B) Immunofluorescence with anti-γ antibody. Note typical subepithelial deposits (original magnification × 312). Kidney International 1999 56, 355-377DOI: (10.1046/j.1523-1755.1999.00548.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Patient 2. (A) Light microscopy. Atypical membranous glomerulonephritis: in addition to the irregular aspect of the capillary walls, note segmental mesangial hypertrophy and cellular proliferation (silver stain; original magnification × 312). (B, C) Immunofluorescence microscopy. Diffuse granular deposits along the capillary walls with predominant subepithelial location. Staining was exclusive for IgG (B) and kappa light chain (C, next page). Original magnification × 312. (D) Electron micrograph of a glomerular capillary. Note subepithelial deposits of fibrillar material cut at various angles. Uranyl acetate and lead citrate (original magnification × 12,000. Reproduced from46). Kidney International 1999 56, 355-377DOI: (10.1046/j.1523-1755.1999.00548.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Patient 3. (A) Light microscopy. Nodular glomerulosclerosis. Note moderate mesangial hypercellularity, scarce double-contour aspects, and normal appearance of most tubular basement membranes. PAS stain (original magnification × 312). (B) Electron micrograph of a glomerular capillary. Note diffuse, finely granular, electron-dense deposits along the glomerular basement membrane with effacement of epithelial cell foot processes (uranyl acetate and lead citrate; original magnification × 12,000). Kidney International 1999 56, 355-377DOI: (10.1046/j.1523-1755.1999.00548.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Patient 3. Epitope analysis of γ-chain deposits by indirect immunofluorescence. Monoclonal antibodies specific for γ-chain constant domains and for γ1 heavy-chain were used. Deposits reacted with NL16, a monoclonal antibody specific for the γ1 subclass. Note staining of the deposits with anti-CH2 and anti-CH3 antibodies but not with the anti-CH1 antibody (original magnification × 312). Kidney International 1999 56, 355-377DOI: (10.1046/j.1523-1755.1999.00548.x) Copyright © 1999 International Society of Nephrology Terms and Conditions