Volume 7, Issue 9, Pages (September 2010)

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Volume 7, Issue 9, Pages 1171-1177 (September 2010) Antiarrhythmic use from 1991 to 2007: Insights from the Canadian Registry of Atrial Fibrillation (CARAF I and II) Jason G. Andrade, MD, Stuart J. Connolly, MD, Paul Dorian, MD, FHRS, Martin Green, MD, Karin H. Humphries, MBA, DSc, George J. Klein, MD, Robert Sheldon, MD, PhD, Mario Talajic, MD, Charles R. Kerr, MD, FHRS Heart Rhythm Volume 7, Issue 9, Pages 1171-1177 (September 2010) DOI: 10.1016/j.hrthm.2010.04.026 Copyright © 2010 Heart Rhythm Society Terms and Conditions

Figure 1 The use of a rhythm control strategy, a rate control strategy, and no medications in AF patients by calendar year in CARAF I and II. AF = atrial fibrillation; CARAF = Canadian Registry of Atrial Fibrillation. Heart Rhythm 2010 7, 1171-1177DOI: (10.1016/j.hrthm.2010.04.026) Copyright © 2010 Heart Rhythm Society Terms and Conditions

Figure 2 The use of a rhythm control strategy, a rate control strategy, and no medications in AF patients from enrolment through to the end of study follow-up (10 years for CARAF I and 5 years for CARAF II). In both CARAF I and CARAF II, the prevalence of chronic AF increased over the duration of follow-up. Mirroring this increase in AF was a steady decline in AAD use. AAD = antiarrhythmic drug; AF = atrial fibrillation; CARAF = Canadian Registry of Atrial Fibrillation. Heart Rhythm 2010 7, 1171-1177DOI: (10.1016/j.hrthm.2010.04.026) Copyright © 2010 Heart Rhythm Society Terms and Conditions

Figure 3 AAD use in AF patients by calendar year in CARAF I and II. AAD = antiarrhythmic drug; AF = atrial fibrillation; CARAF = Canadian Registry of Atrial Fibrillation. Heart Rhythm 2010 7, 1171-1177DOI: (10.1016/j.hrthm.2010.04.026) Copyright © 2010 Heart Rhythm Society Terms and Conditions

Figure 4 Rate control medication use in AF patients by calendar year in CARAF I and II. AF = atrial fibrillation; BB= beta-blocker; CARAF = Canadian Registry of Atrial Fibrillation; CCB = nondihydropyridine calcium channel blocker. Heart Rhythm 2010 7, 1171-1177DOI: (10.1016/j.hrthm.2010.04.026) Copyright © 2010 Heart Rhythm Society Terms and Conditions

Figure 5 Usage of medications to control ventricular rate in patients receiving a rate control strategy (A) and a rhythm control strategy (B). AAD = antiarrhythmic drug; AF = atrial fibrillation; BB = beta-blocker; CARAF = Canadian Registry of Atrial Fibrillation; CCB = nondihydropyridine calcium channel blocker; Dig = digoxin. Heart Rhythm 2010 7, 1171-1177DOI: (10.1016/j.hrthm.2010.04.026) Copyright © 2010 Heart Rhythm Society Terms and Conditions