Volume 154, Issue 5, Pages 1380-1390.e5 (April 2018) Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies  Natalia Khalaf, Chen Yuan, Tsuyoshi Hamada, Yin Cao, Ana Babic, Vicente Morales-Oyarvide, Peter Kraft, Kimmie Ng, Edward Giovannucci, Shuji Ogino, Meir Stampfer, Barbara B. Cochrane, JoAnn E. Manson, Clary B. Clish, Andrew T. Chan, Charles S. Fuchs, Brian M. Wolpin  Gastroenterology  Volume 154, Issue 5, Pages 1380-1390.e5 (April 2018) DOI: 10.1053/j.gastro.2017.12.001 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Forest plot and meta-analysis of odds ratios for pancreatic cancer per standard deviation increase in plasma salicylurate by cohort. CI, confidence interval; HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; OR, odds ratio; WHI-OS, Women’s Health Initiative-Observational Study. Solid squares and horizontal lines indicate cohort-specific multivariable-adjusted ORs and 95% CIs, respectively, per standard deviation increase in plasma salicylurate. Area of the solid square reflects the cohort-specific weight (inverse of the variance). Diamond represents the meta-analysis multivariable-adjusted OR and 95% CI. Vertical line indicates an OR of 1.0. Overall response (95% CIs) from conditional logistic regression models conditioned on matching factors (year of birth, cohort, smoking status, fasting status, and month of blood draw) and adjusted for race (white, black, other, unknown), BMI in kg/m2 (<25.0, 25.0–29.9, 30.0–34.9, ≥35.0, missing), diabetes mellitus (yes/no), alcohol intake in grams/day (0, 0.1–4.9, 5.0–14.9, 15.0–29.9, ≥30.0, missing), multivitamin use (yes/no), physical activity (quintiles), and regular non-aspirin NSAID use (yes/no/missing). Gastroenterology 2018 154, 1380-1390.e5DOI: (10.1053/j.gastro.2017.12.001) Copyright © 2018 AGA Institute Terms and Conditions