A Blend of Sesame and Rice Bran Oils Lowers Hyperglycemia and Improves the Lipids Sankar Devarajan, PhD, Biprabuddha Chatterjee, MSc, Hidenori Urata,

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A Blend of Sesame and Rice Bran Oils Lowers Hyperglycemia and Improves the Lipids Sankar Devarajan, PhD, Biprabuddha Chatterjee, MSc, Hidenori Urata, MD, PhD, Bo Zhang, PhD, Amanat Ali, PhD, Ravinder Singh, MBBS, MPH, Sambandam Ganapathy, MBBS, PhD The American Journal of Medicine Volume 129, Issue 7, Pages 731-739 (July 2016) DOI: 10.1016/j.amjmed.2016.02.044 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Study design. HbA1c = glycated hemoglobin. The American Journal of Medicine 2016 129, 731-739DOI: (10.1016/j.amjmed.2016.02.044) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Box-and-whisker plots showing the mean (▪), median (middle bar in the rectangle), and 10th (bottom bar), 25th (bottom of rectangle), 75th (top of rectangle), and 90th (top bar) percentiles of changes in fasting (FBG) and postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) (A) and serum lipids (B) in normoglycemic subjects and type 2 diabetes mellitus patients treated with sesame oil blend (left panel) and type 2 diabetes mellitus patients who were treated with glibenclamide with and without receiving sesame oil blend (right panel) at baseline and week 8 of the study. *P <.05, within-group changes (week 8 vs baseline), assessed by Wilcoxon signed-rank test. †P <.05, changes between groups (type 2 diabetes mellitus patients vs normoglycemic subjects who received sesame oil blend or glibenclamide-treated patients with type 2 diabetes mellitus who received and did not receive sesame oil blend), assessed by Wilcoxon rank sum test. HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; TG = triglycerides. The American Journal of Medicine 2016 129, 731-739DOI: (10.1016/j.amjmed.2016.02.044) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Dependence of the effects of sesame oil blend on fasting (FBG) and postprandial (PBG) blood glucose, and glycated hemoglobin (HbA1c) (A) and serum lipids and lipoproteins (B) on their baseline levels in normoglycemic subjects, type 2 diabetes mellitus patients with and without sesame oil blend treatment. (A) Scatter plot of changes (Δ) in FBG vs baseline FBG, ΔPBG vs baseline PBG, and ΔHbA1c vs baseline HbA1c in normoglycemic subjects (in black color) and type 2 diabetes mellitus patients (in red color) (left panel) and type 2 diabetes mellitus patients with (in green color) and without (in blue color) sesame oil blend treatment (right panel). (B) Scatter plot of changes (Δ) in triglycerides (TG) vs baseline TG, Δhigh-density lipoprotein cholesterol (ΔHDL-C) vs baseline HDL-C, and Δlow-density lipoprotein cholesterol (ΔLDL-C) vs baseline LDL-C, and Δnon-HDL-C vs baseline non-HDL-C in normoglycemic subjects (in black color) and type 2 diabetes mellitus patients (in red color) (left panel) and type 2 diabetes mellitus patients with (in green color) and without (in blue color) sesame oil blend treatment (right panel). (Color illustration appears online.) The American Journal of Medicine 2016 129, 731-739DOI: (10.1016/j.amjmed.2016.02.044) Copyright © 2016 Elsevier Inc. Terms and Conditions