Volume 152, Issue 2, Pages (August 2017)

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Volume 152, Issue 2, Pages 368-378 (August 2017) A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa Pallavi Bedi, MD, James D. Chalmers, PhD, Catriona Graham, MSc, Andrea Clarke, MSc, Samantha Donaldson, BSc, Catherine Doherty, PhD, John R.W. Govan, DSc, Donald J. Davidson, PhD, Adriano G. Rossi, DSc, Adam T. Hill, MD CHEST Volume 152, Issue 2, Pages 368-378 (August 2017) DOI: 10.1016/j.chest.2017.05.017 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Consort diagram of recruitment. CHEST 2017 152, 368-378DOI: (10.1016/j.chest.2017.05.017) Copyright © 2017 The Authors Terms and Conditions

Figure 2 A-C, Serum inflammatory markers. Serum CXCL8 (A), serum TNF (B), and serum ICAM-1 (C), showing mean change and SEM. CXCL8 = interleukin 8; ICAM-1 = intercellular adhesion molecule 1; TNF = tumor necrosis factor. CHEST 2017 152, 368-378DOI: (10.1016/j.chest.2017.05.017) Copyright © 2017 The Authors Terms and Conditions

Figure 3 A-C, fMLF-stimulated serum neutrophils increased CD11b expression, and this was significantly reduced when neutrophils were pretreated with 10 μM of atorvastatin (**P = .02). This was comparable to the positive control in the experiment—CSH, a known formyl peptide receptor 1 (FPR1) antagonist; *P = .03. B, There was no effect on fMLF-induced CD62L shedding. C, Cumulative data from N = 5 experiments showing that atorvastatin and CSH were able to reduce fMLF induced CD11b expression. Ator = atorvastatin; CSH = cyclosporin H; FLI = fluorescence index; fMLF = formyl-methionyl-leucyl phenylalanine. CHEST 2017 152, 368-378DOI: (10.1016/j.chest.2017.05.017) Copyright © 2017 The Authors Terms and Conditions

Figure 4 A, B, fMLF increases [Ca2+] flux when added to serum neutrophils. This was reduced by atorvastatin in a concentration-dependent manner when neutrophils were pretreated with atorvastatin prior to adding fMLF. See Figure 3 legend for expansion of abbreviations. CHEST 2017 152, 368-378DOI: (10.1016/j.chest.2017.05.017) Copyright © 2017 The Authors Terms and Conditions