Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by surgery for stage II to III esophageal squamous cell carcinoma Arianna.

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Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by surgery for stage II to III esophageal squamous cell carcinoma Arianna Barbetta, MD, Meier Hsu, MS, Kay See Tan, PhD, Dessislava Stefanova, MD, Koby Herman, MD, Prasad S. Adusumilli, MD, Manjit S. Bains, MD, Matthew J. Bott, MD, James M. Isbell, MD, Yelena Y. Janjigian, MD, Geoffrey Y. Ku, MD, Bernard J. Park, MD, Abraham J. Wu, MD, David R. Jones, MD, Daniela Molena, MD The Journal of Thoracic and Cardiovascular Surgery Volume 155, Issue 6, Pages 2710-2721.e3 (June 2018) DOI: 10.1016/j.jtcvs.2018.01.086 Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Overall survival, stratified according to treatment. CRT, Chemoradiotherapy; trimodality, neoadjuvant chemoradiotherapy followed by surgery; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Kaplan–Meier curve showing disease-free survival, stratified according to treatment group. CRT, Chemoradiotherapy; trimodality, neoadjuvant chemoradiotherapy followed by surgery; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Cumulative incidence of local recurrence (LR). CRT, Chemoradiotherapy; trimodality, neoadjuvant chemoradiotherapy followed by surgery; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Cumulative incidence of regional (A) and distant (B) recurrence. RR, Regional recurrence; CRT, chemoradiotherapy; trimodality, neoadjuvant chemoradiotherapy followed by surgery; CI, confidence interval; DR, distant recurrence. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Consolidated Standards of Reporting Trials flow diagram showing selection of patients included in the current study, on the basis of inclusion and exclusion criteria. SCC, Squamous cell carcinoma; cStage, clinical stage; CRT, chemoradiotherapy; trimodality, neoadjuvant chemoradiotherapy followed by surgery. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Overall survival stratified according to treatment. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Video 1 Daniela Molena, MD, discussing the implications of the study. Video available at: http://www.jtcvsonline.org/article/S0022-5223(18)30370-2/fulltext. The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721 The Journal of Thoracic and Cardiovascular Surgery 2018 155, 2710-2721.e3DOI: (10.1016/j.jtcvs.2018.01.086) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions