Volume 94, Issue 3, Pages (September 2018)

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Volume 94, Issue 3, Pages 599-607 (September 2018) Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactions Carl D. Langefeld, Mary E. Comeau, Maggie C.Y. Ng, Meijian Guan, Latchezar Dimitrov, Poorva Mudgal, Mitzie H. Spainhour, Bruce A. Julian, Jeffrey C. Edberg, Jennifer A. Croker, Jasmin Divers, Pamela J. Hicks, Donald W. Bowden, Gary C. Chan, Lijun Ma, Nicholette D. Palmer, Robert P. Kimberly, Barry I. Freedman Kidney International Volume 94, Issue 3, Pages 599-607 (September 2018) DOI: 10.1016/j.kint.2018.03.017 Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure 1 Genome-wide association meta-analysis for end-stage renal disease adjusting for apolipoprotein L1 gene (APOL1) renal-risk genotype status (admixture proportion, age, and gender as covariates). Kidney International 2018 94, 599-607DOI: (10.1016/j.kint.2018.03.017) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure 2 Genome-wide end-stage renal disease case-only analysis of interaction between the apolipoprotein L1 gene (APOL1) and single nucleotide polymorphisms (LPA, lipoprotein [a]; PLG, plasminogen; OTOGL, otogelin-like genes). Kidney International 2018 94, 599-607DOI: (10.1016/j.kint.2018.03.017) Copyright © 2018 International Society of Nephrology Terms and Conditions