Immunohistochemical staining for fibrin in wounds from Plg+/+ and Plg−/− mice treated with galardin or vehicle 7 days after surgery. Immunohistochemical.

Slides:

Advertisements

Similar presentations

Hyp mice show hypertension and increased NCC expression and phosphorylation A–ESerum intact Fgf23 concentration (A, n = 8–9, Student's t‐test, *P =

Advertisements

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Validating Cdk‐dependent chromatin association changes of selected outliers A–EValidation of changes in chromatin affinity following Cdk inhibition of.

Induction of apoptosis or senescence depends on the level of TRF2ΔBΔM expression in mouse liver. Induction of apoptosis or senescence depends on the level.

Mouse Carotid Artery Ligation Induces Platelet-Leukocyte–Dependent Luminal Fibrin, Required for Neointima Development by Tomihisa Kawasaki, Mieke Dewerchin,

Microscopic appearance of skin wounds in mock‐ and galardin‐treated Plg‐deficient and wild‐type mice. Microscopic appearance of skin wounds in mock‐ and.

Spontaneous and inducible arrhythmias in dnNRSF Tg mice.

Analysis of the effect of loss of Brca2 on in vivo somatic mutation frequency and mutation type. Analysis of the effect of loss of Brca2 on in vivo somatic.

Lsh does not regulate global histone methylation levels.

Phosphorylation of RelA Ser311 in vivo.

Accumulation of 2,4‐dienoyl‐CoA ester (C22:7) during β‐oxidation of docosahexaenoic acid (C22:6). Accumulation of 2,4‐dienoyl‐CoA ester (C22:7) during.

FtsK‐independent dif recombination in the presence of HinXerC.

Phenotypes of GATA‐1.05/Y germline mutant embryos expressing wild‐type or mutant GATA‐1 transgenes. Phenotypes of GATA‐1.05/Y germline mutant embryos expressing.

Measurement of terminal restriction fragments (TRFs) in bone marrow cells from both parents and the G4 progeny. Measurement of terminal restriction fragments.

Morphological analyses of peripheral blood and bone marrow cells isolated from leukemic mice. Morphological analyses of peripheral blood and bone marrow.

HMGB1 is required for the in vivo adjuvant activity of necrotic cells.

PERK activator decreases pathological tau species in vivo

TRF2ΔBΔM induces apoptosis and senescence in the mouse liver.

Cognitive deficits in APPPS1‐21 mice.

Control of IL‐6 synthesis by ζPKC and RelA Ser311 phosphorylation.

ERM proteins are essential for efficient cell‐to‐cell spread of Listeria. ERM proteins are essential for efficient cell‐to‐cell spread of Listeria. (A–D)

Organization of large regions within cerebral organoids

Aberrant wound architecture and proliferation in Rev3l-deficient skin.

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

Metabolic profile of Tfe3 KO mice

Impaired fear extinction precedes memory decline in Fmn2 mutant mice

Representative histopathology images from the knee joints and ankle of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA.

Effects of GM1 on astroglial and microglial markers

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

TFE3 prevents diet‐induced obesity and metabolic syndrome

Correlation between Aβ deposition in the brain (PET) and the Aβ secondary structure distribution in plasma Correlation between Aβ deposition in the brain.

Stromal fibromuscular AR regulates epithelium proliferation, ECM remodelling, neovasculature formation and immune cell infiltration in Pten deficient mice.

Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding, or TPA. Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding,

Combination of OTX‐015 and PD does not induce overt toxicity

Reduced expression and phosphorylation of NCC in SPAK243A/243A mice.

T22‐GFP‐H6‐FdU‐induced reduction in tumor re‐initiation capacity and blockade of tumor emboli intravasation in the CXCR4+ patient‐derived M5 model T22‐GFP‐H6‐FdU‐induced.

The TGF-β pathway is activated in the skin after C

Intra‐eWAT administration of FGF21 vectors in ob/ob mice

Nec‐1 inhibits the phosphorylation and aggregation of tau

Histological changes in mouse colons after DSS treatment.

The psoriatic phenotype of DKO

The ER is the main source of cholesterol accumulated by STARD3 in endosomes The ER is the main source of cholesterol accumulated by STARD3 in endosomes.

Association of AIM2, RIG‐I and NLRP3 inflammasomes with better survival in NPC patients.A.Overexpression of ASC, caspase‐1 and IL‐1β proteins as well as.

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

MTORC1 activation and Myc expression signature in atypical cysts and neoplasms.A–O.Serial sections of a simple cyst (A,D,G,J,M) and two neoplasms (B,E,H,K,N.

Gain of FGF23 function induces renal Na+ retention through increased renal NCC expression and channel activation AUrine volume (n = 15–17), urinary Na+

Assessment of proliferation status of PDGFRα+ cells in developing mouse lungs Assessment of proliferation status of PDGFRα+ cells in developing mouse lungs.

Effect of memantine on Klk7‐dependent Aβ degradation activity

Combined targeting of PCa AR and CCL2/CCR2 axis suppresses tumour growth and reduces metastasis in a xenograft mouse PCa model Proliferation assay of TRAMP‐C1.

MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.

Both the number and the OX40L expression level of bronchiolar progenitors were increased by influenza infection. Wild‐type mice were intratracheally infected.

Therapeutic role of TR in HFD‐established diabetic mice

Treatment with AZD5363 reduces the proportion of proliferating vascular endothelial cells and following RT, the influx of CD11b+ bone marrow‐derived cells.

Etifoxine modulation of T‐cell activity during EAE

Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,

Dual‐recombinase fluorescence lineage tracing of EMT in KPF (FSF‐KrasG12D/+;Trp53frt/+;Pdx1‐Flp);αSMA‐Cre;R26Dual mice Dual‐recombinase fluorescence lineage.

The MEK inhibitor CI‐1040 reverses thickening, fibrosis, and angiogenesis in the parietal peritoneum of Cav1−/− mice upon exposure to PD fluidWT or Cav1−/−

Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.

Sox2 is essential for SLG regeneration following radiation injury

Expression of Hox genes, ALK5, GDF11 and ALK4 in Alk5−/− mutants.

CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair.

The oligoclonal antibody overcomes the C797S mutation‐mediated resistance to osimertinib The oligoclonal antibody overcomes the C797S mutation‐mediated.

Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:

Effect of PEDF+DHA treatment on wound healing in diabetic corneas.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

A: Photomicrograph of a fibrin gel containing ∼50 islets 2 h after polymerization of a 5-μl fibrinogen solution containing the islets with 5 μl thrombin.

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

In vivo thrombosis of tumor vasculature.

YH25448 less suppresses WT EGFR than osimertinib in vivo.

Figure 4. Histologic views of wound healing at day 7 with light microscopic findings (H&E stain, 100× magnification). Newly formed bone was seen from the.

Presentation transcript:

Immunohistochemical staining for fibrin in wounds from Plg+/+ and Plg−/− mice treated with galardin or vehicle 7 days after surgery. Immunohistochemical staining for fibrin in wounds from Plg+/+ and Plg−/− mice treated with galardin or vehicle 7 days after surgery. Sections from mock‐treated wild‐type (a) and plasminogen‐deficient (b) mice, and from galardin‐treated wild‐type (c) and plasminogen‐deficient (d) mice were stained immunohistochemically for fibrin(ogen). Both in the wild‐type mice treated with galardin and in the Plg‐deficient mice treated with either vehicle or galardin, fibrillar deposits are seen containing fibrin in front of and below the epidermal outgrowth (small straight arrows). There is no apparent difference in the intensity of the fibrin staining between the wild‐type mice treated with galardin and the Plg‐deficient mice treated with either vehicle or galardin. The open arrows in (a–d) show the ends of the epidermal outgrowth. Magnification, ×170. Leif R. Lund et al. EMBO J. 1999;18:4645-4656 © as stated in the article, figure or figure legend