Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood- Related Traits Alanna C. Morrison, Zhuoyi Huang, Bing Yu, Ginger Metcalf,

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Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood- Related Traits Alanna C. Morrison, Zhuoyi Huang, Bing Yu, Ginger Metcalf, Xiaoming Liu, Christie Ballantyne, Josef Coresh, Fuli Yu, Donna Muzny, Elena Feofanova, Navin Rustagi, Richard Gibbs, Eric Boerwinkle The American Journal of Human Genetics Volume 100, Issue 2, Pages 205-215 (February 2017) DOI: 10.1016/j.ajhg.2016.12.009 Copyright © 2017 American Society of Human Genetics Terms and Conditions

Figure 1 Overall Analytic Approach The American Journal of Human Genetics 2017 100, 205-215DOI: (10.1016/j.ajhg.2016.12.009) Copyright © 2017 American Society of Human Genetics Terms and Conditions

Figure 2 Annotated Functional Motifs The American Journal of Human Genetics 2017 100, 205-215DOI: (10.1016/j.ajhg.2016.12.009) Copyright © 2017 American Society of Human Genetics Terms and Conditions

Figure 3 Survey of the Genomic Landscape on Chromosome 6q25.3-6q26 for Lp(a) Levels via Lachesis The sliding window trace shows the results from tests (SKAT and T5) aggregating low-frequency and rare variation within overlapping physical windows of 4 kb. Significant results are shown for regulatory domains in SLC22A3 (SKAT) and PLG (T5) and the first intron of SLC22A3 (SKAT). Results after conditioning on rs115848955 in LPA are also shown. The American Journal of Human Genetics 2017 100, 205-215DOI: (10.1016/j.ajhg.2016.12.009) Copyright © 2017 American Society of Human Genetics Terms and Conditions

Figure 4 Survey of the Genomic Landscape on Chromosome 1q23 for Neutrophil Count via Lachesis The sliding window trace shows the results from tests (SKAT and T5) aggregating low-frequency and rare variation within overlapping physical windows of 4 kb. Significant results are shown for regulatory domains in DARC (T5 and SKAT) and CADM3 (SKAT). Results after conditioning on rs2814778 in DARC are also shown. The American Journal of Human Genetics 2017 100, 205-215DOI: (10.1016/j.ajhg.2016.12.009) Copyright © 2017 American Society of Human Genetics Terms and Conditions