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Volume 57, Issue 2, Pages 342-349 (February 2010) Localization and Function of Cannabinoid Receptors in the Corpus Cavernosum: Basis for Modulation of Nitric Oxide Synthase Nerve Activity Christian Gratzke, George J. Christ, Christian G. Stief, Karl-Erik Andersson, Petter Hedlund European Urology Volume 57, Issue 2, Pages 342-349 (February 2010) DOI: 10.1016/j.eururo.2008.12.024 Copyright © 2009 Terms and Conditions

Fig. 1 Western blot analysis: The cannabinoid agonist 1 (CB1), CB2, and transient receptor potential V1 (TRPV1) antibody detected clear bands of the expected molecular weights (60kDa, 60kDa, and 100kDa) in tissue from the nonhuman primate corpus cavernosal smooth muscle. European Urology 2010 57, 342-349DOI: (10.1016/j.eururo.2008.12.024) Copyright © 2009 Terms and Conditions

Fig. 2 Cannabinoid agonist 1 (CB1) and CB2 immunoreactivity (IR) was found in nerve fibers within and between strands of corpus cavernosal (CC) smooth muscle. CB1-IR (A: human CC, ×1000 magnification) and CB2- IR (B: upper panel: primate CC, ×600 magnification; lower panel: human CC, ×1000 magnification) nerves also expressed immunoreactivity for nitric oxide synthase (NOS). European Urology 2010 57, 342-349DOI: (10.1016/j.eururo.2008.12.024) Copyright © 2009 Terms and Conditions

Fig. 3 A: Cannabinoid agonist 1 (CB1) immunoreactivity (IR) (upper panel: human corpus cavernosal [CC] tissue) or CB2-IR (lower panel: human CC) was coexpressed with transient receptor potential V1 (TRPV1)-IR in varicose nerve terminals (×1000 magnification). B: Neither CB1-IR (upper panel: human CC, ×200 magnification) nor CB2-IR (lower panel: human CC) was located for nerve fibers expressing tyrosine hydroxylase (TH)-IR (×400 magnification). European Urology 2010 57, 342-349DOI: (10.1016/j.eururo.2008.12.024) Copyright © 2009 Terms and Conditions

Fig. 4 Phenylephrine concentration–response curves (CRCs) before and after administration of anandamide (10μM) on isolated primate corpus cavernosal smooth-muscle preparations (n=6). Values represent mean plus or minus standard error of the mean. European Urology 2010 57, 342-349DOI: (10.1016/j.eururo.2008.12.024) Copyright © 2009 Terms and Conditions

Fig. 5 A: Effects of electrical field stimulation (EFS) before and after administration of anandamide (10μM, left) on isolated corporal smooth muscle preparations (n=6). Values represent mean plus or minus standard error of the mean. B: Original tracings show the effects of anandamide on nerve-induced relaxations. European Urology 2010 57, 342-349DOI: (10.1016/j.eururo.2008.12.024) Copyright © 2009 Terms and Conditions