Volume 64, Issue 4, Pages 1425-1436 (October 2003) Predicting GFR in children and adults: A comparison of the Cockcroft-Gault, Schwartz, and Modification of Diet in Renal Disease formulas  Annick Pierrat, Elisabeth Gravier, Claude Saunders, Marie-Véronique Caira, Zakia Aït-Djafer, Bernard Legras, Jean-Pierre Mallié  Kidney International  Volume 64, Issue 4, Pages 1425-1436 (October 2003) DOI: 10.1046/j.1523-1755.2003.00208.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Values of glomerular filtration rate (GFR) measured or estimated in the different groups of children. (A) All children (C-All), all three groups (N = 198 patients). (B) Nonsingle kidney nontransplanted (C-NSK-NTR) (N = 138). (C) Single kidney (C-SK) (N = 30). (D) Transplanted kidney (C-TR), transplanted (N = 30). Abbreviations are: Cin, inulin clearance corrected for body surface area (BSA); Cinnc, noncorrected inulin clearance; Ccr, creatinine clearance corrected for BSA; Ccrnc, noncorrected creatinine clearance; Cck, estimation with Cockcroft-Gault formula; Sch, estimation with Schwartz formula; and MDRD, estimation with the Modification of Diet in Renal Disease group urinary formula. See Methods section. *P vs. inulin clearance <0.05; **P vs. inulin clearance <0.02; ***P vs. inulin clearance <0.01; *****P vs. inulin clearance <0.0001 and less. Kidney International 2003 64, 1425-1436DOI: (10.1046/j.1523-1755.2003.00208.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Values of glomerular filtration rate (GFR) measured or estimation in children according to age groups. (A) Younger than 8 years old (<8) (N = 20). (B) Between 8 and 12 years old (8–12) (N = 62). (C) Older than 12 years (>12) (N = 116). Abbreviations are: Cin, inulin clearance corrected for body surface area (BSA); Cinnc, noncorrected inulin clearance; Ccr, creatinine clearance corrected for BSA; Ccrnc, noncorrected creatinine clearance; Cck, estimation with Cockcroft-Gault formula; Sch, estimation with Schwartz formula; MDRD, estimation with the Modification Diet in Renal Disease group urinary formula. See Methods section. **P vs. inulin clearance <0.02; ***P vs. inulin clearance <0.01; ****P vs. inulin clearance <0.001; *****P vs. inulin clearance <0.0001 and less. Kidney International 2003 64, 1425-1436DOI: (10.1046/j.1523-1755.2003.00208.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Values of glomerular filtration rate (GFR) measured or estimated in adults. (A) A-All (single kidney + transplanted) (SK+ TR) (N = 116 patients). (B) A-single kidney (SK) single kidney (N = 28). (C) A-transplanted (TR) (N = 88). Abbreviations are: Cin: inulin clearance corrected for body surface area (BSA); Cinnc, noncorrected inulin clearance; Ccr, creatinine clearance corrected for BSA; Ccrnc, noncorrected creatinine clearance; Cck, estimation with Cockcroft-Gault formula; MDRD, estimation with the Modification Diet in Renal Disease group urinary formula. See Methods section. *P vs. inulin clearance <0.05; **P vs. inulin clearance <0.02; ****P vs. inulin clearance <0.001; *****P vs. inulin clearance <0.0001 and less. Kidney International 2003 64, 1425-1436DOI: (10.1046/j.1523-1755.2003.00208.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Comparison between glomerular filtration rate (GFR) in mL/min measured in children (C-All) (N = 198) by inulin clearance corrected for body surface area (BSA) and the estimated GFR using the Cockcroft-Gault formula (A); the Schwartz formula (B) and the Modification of Diet in Renal Disease (MDRD) group urinary formula (C). In each panel, the graph on the left represents the regression statistics. Inulin clearance is indicated on the Y-axis and the estimated value (Cockcroft-Gault, Schwartz, or MDRD) on the X-axis. The line represents the linear coefficient of regression r indicated in the graph with the values of the 95% interval of confidence in parenthesis. The graph on the right is the concordance study using the Bland-Altman method. X and Y are the values plotted on X- and Y-axis, respectively, in the linear regression graph on the left. The Y-axis is X—Y and the X-axis (X + Y)/2. The center line represents the mean of the differences between the two values for each individual; it is close to 0 (-2mL/min/1.73m2) for Cockcroft-Gault and different from 0 (-20mL/min/1.73m2) for both Schwartz and MDRD. The upper and lower lines indicate the 95% distribution of the population. Kidney International 2003 64, 1425-1436DOI: (10.1046/j.1523-1755.2003.00208.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Comparison between glomerular filtration rate (GFR) in mL/min measured in adults (A-All) (N = 116) by inulin clearance corrected for body surface area (BSA) and the estimated GFR using the Cockcroft-Gault formula (A) and the Modification of Diet in Renal Disease (MDRD) group urinary formula (B). In each panel, the graph on the left represents the regression statistics. Inulin clearance is indicated on the Y-axis and the estimated value (Cockcroft-Gault or MDRD) on the X-axis. The line represents the linear coefficient of regression r indicated in the graph with the values of the 95% interval of confidence in parenthesis. The graph on the right is the concordance study using the Bland-Altman method. X and Y are the values plotted on X- and Y-axis, respectively, in the linear regression graph on the left. The Y-axis is X—Y and the X-axis (X + Y)/2. The center line represents the mean of the differences between the two values for each individual; it is close to 0 for Cockcroft-Gault and MDRD. The upper and lower lines indicate the 95% distribution of the population. Kidney International 2003 64, 1425-1436DOI: (10.1046/j.1523-1755.2003.00208.x) Copyright © 2003 International Society of Nephrology Terms and Conditions