Spike detected fMRI - SfMRI

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Presentation transcript:

Spike detected fMRI - SfMRI Simultaneous EEG recording during fMRI acquisition Acquire multislice fMRI in blocks of 10 minutes during EEG recording Post-processing of EEG to identify images where either ictal or interictal abnormalities are present Interleave with specific cognitive or other functional tasks Analyze by SPM by comparing images acquired where EEG is normal with those with ictal and interictal abnormalities November 24, 2018

Characteristic EEG Pattern of CAE November 24, 2018

Simultaneous EEG and fMRI Use of pre- and post-acquisition artifact reduction measures have enabled us to obtain high-quality EEG recordings. ( Negishi M, R. T. Constable, et al., 2004 ) Example of EEG in a 13 year old girl with CAE who had an absence seizure during fMRI (Berman R., and Negishi, M., AES Abstract 2005). The in-magnet EEG data is of sufficient quality to reveal SWD R Berman, EJ Novotny, M Negishi, RT Constable, H Blumenfeld 2006 . November 24, 2018

Impaired performance during Seizures Responses Missed Targets Example of an absence seizure (EEG artifact removed) in a 12 year old CAE patient during simultaneous EEG and 3T fMRI. R Berman, EJ Novotny, M Negishi, RT Constable, H Blumenfeld 2006 November 24, 2018

BOLD fMRI changes during seizures Tested 12 patients with CAE, 3 had seizures during scanning Obtained a total of 11 seizure episodes (4-12 sec) during 4 sessions Increases Decreases Bilateral Thalamus Dorsolateral Frontal Lateral parietal Superior temporal Occipital Anterior Cingulate Dorsal parietal Retrosplenial Pons Cerebellum p<0.001, k=3 Example of BOLD fMRI changes during a single 12 second absence seizure in a 12 year old patient with typical CAE. November 24, 2018

Group Analysis of Timecourse of BOLD Signal during Absence S November 24, 2018

Simultaneous EEG/fMRI Application as part of presurgical evaluation Interictal Spikes with SfMRI Preliminary study of > 60 subjects – results are comparable to FDG - PET November 24, 2018

Simultaneous EEG/fMRI Novel method combining clinical neurophysiological and functional imaging measures of function simultaneously Investigation of relationship of structure and function noninvasively Potential areas of study Epilepsy Origin of normal EEG patterns/Sleep Event related potentials Integration with other imaging modalities – MEG, PET, SPECT, MRSI, DTI, …. November 24, 2018