Sky W. Brubaker, Denise M. Monack Immunity

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Cell-Intrinsic Defense at the Epithelial Border Wall: Salmonella Pays the Price Sky W. Brubaker, Denise M. Monack Immunity Volume 46, Issue 4, Pages 522-524 (April 2017) DOI: 10.1016/j.immuni.2017.03.021 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 NAIP-NLRC4 Inflammasome Activation within the Cytosol of Intestinal Epithelial Cells During Salmonella infection, the NAIP-NLRC4 inflammasome can activate either Caspase-1 or Caspase-8, triggering an IEC-intrinsic response that limits bacterial burden. Caspase-1 activation results in a coordinated rapid cell death (pyroptosis) and cell expulsion, whereas Caspase-8 activation results in cell expulsion without coordinated cell death. Dotted arrows indicate mechanisms that remain to be characterized. Immunity 2017 46, 522-524DOI: (10.1016/j.immuni.2017.03.021) Copyright © 2017 Elsevier Inc. Terms and Conditions