Targeting MET in Lung Cancer: Will Expectations Finally Be MET?

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Presentation transcript:

Targeting MET in Lung Cancer: Will Expectations Finally Be MET? Alexander Drilon, MD, Federico Cappuzzo, MD, PhD, Sai-Hong Ignatius Ou, MD, PhD, D. Ross Camidge, MD, PhD Journal of Thoracic Oncology Volume 12, Issue 1, Pages 15-26 (January 2017) DOI: 10.1016/j.jtho.2016.10.014 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 (A) Time line of discovery in lung cancers harboring alterations of the hepatocyte growth factor receptor (MET) pathway. (B) The MET receptor and selected MET pathway–directed targeted therapies. MET, MET proto-oncogene receptor tyrosine kinase; HGF, hepatocyte growth factor; mAb, monoclonal antibody; PSI, plexin-semaphorin-integrin; IPT, immunoglobulin-plexin transcription; TKI, tyrosine kinase inhibitor. Journal of Thoracic Oncology 2017 12, 15-26DOI: (10.1016/j.jtho.2016.10.014) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 The pathobiology of MET proto-oncogene receptor tyrosine kinase (MET) exon 14 alterations and MET amplification. MET, hepatocyte growth factor receptor; CEP7, centromeric portion of chromosome 7. Journal of Thoracic Oncology 2017 12, 15-26DOI: (10.1016/j.jtho.2016.10.014) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions