What does this protein make up or do? Charcot–Marie–Tooth disease Chapter 10: Chromosome 10 DNA Sequence Chromosome 35,581 Name of Protein 10 Name of Gene periphal myelin PMP22 transcription Amino acid sequence mRNA 160 aa Cytoplasm translation What does this protein make up or do? A Cell Nucleus Involved in growth regulation in myelination in the peripheral nervous system Condition/Disease Charcot–Marie–Tooth disease

Description of : Charcot–Marie–Tooth disease Symptoms and characteristics -Charcot (shahr-KOH)-Marie-Tooth disease is a group of hereditary disorders that damage the nerves in your arms and legs (peripheral nerves). -If foot deformities are severe, corrective foot surgery may help alleviate pain and improve your ability to walk. But surgery can't improve weakness or loss of sensation -Complications of Charcot-Marie-Tooth disease vary in severity from person to person, with foot abnormalities and difficulty walking generally being the most serious problems. Muscle weakness may also increase, and injury to areas of the body with decreased sensation may occur. -Charcot–Marie–Tooth disease can be detected through a physical exam.

Description of: Charcot–Marie–Tooth disease (cont.) Who is affected? Anyone, but the following have a higher risk: -Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but this condition can develop in midlife too. Outlook or quality of life -There's no cure for Charcot-Marie-Tooth disease. But, the disease generally progresses slowly, and the expected length of life isn't shortened by the disorder. Researcher: BH

References 1. http://onlinelibrary.wiley.com/doi/10.1002/humu.20953/abstract 2. http://en.wikipedia.org/wiki/Charcot%E2%80%93Marie%E2%80%93Tooth_disease 3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972637/