Melting behavior of protein complexes

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Melting behavior of protein complexes Melting behavior of protein complexes AMelting behavior of protein complexes from human and Escherichia coli was measured by the average Euclidean distance between the melting curves of proteins from each complex. Line represents the median, box represents the interquartile range, and whiskers of the box plots represent the 10th and 90th percentiles. Pie charts represent the fraction of protein complexes that melt coherently (compared with a distribution of 10,000 random complexes; P < 0.05).BComparison of the melting behavior of protein complexes located in a single cellular compartment or in multiple compartments. Line represents the median, box represents the interquartile range, and whiskers of the box plots represent the 10th and 90th percentiles. Pie charts represent the fraction of protein complexes that melt coherently (compared with a distribution of 10,000 random complexes; P < 0.05).CSchematic representation of complexes located in a single cellular compartment or in multiple compartments.D–HMelting curves for examples of non‐co‐melting complexes located in the same cellular compartment: (D) ClpP protease complex, (E) Ruv DNA repair complex, (F) Uvr DNA repair complex, (G) Suf Fe‐S biogenesis complex, and (H) Bam outer membrane porin assembly complex. P indicates the probability that the complex melts coherently (compared with a distribution of 10,000 random complexes). André Mateus et al. Mol Syst Biol 2018;14:e8242 © as stated in the article, figure or figure legend