100,000 Genomes Haematolgical Malignancies Update Week ending 27th July 2018

Haem Onc Recruitment

Haem Onc Recruitment Forecast

Haem Onc UKB Submitted UKB SUBMISSION 27/07/2018 Row Labels Haemonc Haemonc_AML haemonc_ cll Haemonc_ Lymphoma Haemonc_multiple myeloma MDS Grand Total Greater Manchester 22 2 24 North East and Cumbria 12 North Thames 84 Oxford 74 14 6 4 100 South London 30 Wessex West London 36 West Midlands 34 West of England 326 354

Updates Haem Onc Webex held on 6th July Haem Onc WGS reporting guidance First Myeloma results Update on progress with validation cohorts Monthly Haem Onc Leads Calls (next is on Wednesday 29th August) Measures to facilitate recruitment of Haematological Participants Programme extension (now all Cancer) Reduced DNA requirements for germline DNA in Haematological Malignancies* Germline validation pilots Uncultured skin biopsy Enriched T- Cells (for myeloid malignancies) ·        *Whenever possible at least 4ug of DNA should be sent for germline as this will allow for any repeat testing that may be necessary. Where it is not possible to send 4ug of DNA it is permissible to submit less (absolute minimum of 1.3ug, with a minimum concentration of 20ng/ul and minimum volume of 66ul). Service desk must be notified when sending <4ug.