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Volume 44, Issue 3, Pages 329-336 (September 2003) Angiogenetic Protooncogene ets-1 Induced Neovascularization Is Involved in the Metastatic Process of Testicular Germ Cell Tumors Mirko Adam, Doris Schmidt, Eva Wardelmann, Nicolas Wernert, Peter Albers European Urology Volume 44, Issue 3, Pages 329-336 (September 2003) DOI: 10.1016/S0302-2838(03)00262-8

Fig. 1 Percentage of VEGF-positive histological subtypes in stage I and stage II NSGCT (Ter: teratoma; EC: embryonal carcinoma; YS: yolksac tumor; Sem: seminoma). European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 2 Percentage of ets-1 positive histological subtypes in stage I vs. stage II NSGCT (Ter: teratoma; EC: embryonal carcinoma; YS: yolksac tumor; Sem: seminoma). European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 3 Picture II shows strong (+++) ets-1 expression of a stage II teratoma component. In contrast, a stage I seminoma component with only weak (+) expression for ets-1 (picture I). ((−) = no expression, (+) = weak expression, (++) = medium expression, (+++) = strong expression). European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 4 Microvessel density determined by CD105 was significantly higher in stage II compared to stage I NSGCT (p=0.007). European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 5 In contrast to microvessel density determined by CD105 (brown vessel staining) in picture IV (100×), picture III shows the identical spot (100×) of a stage I embryonal carcinoma with higher microvessel density if the CD34 marker (red vessel staining) was used what might be due to false positive staining with this unspecific pan-endothelial marker. European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 6 Distribution of median microvessel density determined by CD105 in histological subtypes of stage I and stage II NSGCT (Ter: teratoma; EC: embryonal carcinoma; YS: yolksac tumor; Sem: seminoma). European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 7 Picture VI shows a stage II embryonal carcinoma with high microvessel density compared to only sparse microvessel density in a stage I embryonal carcinoma (picture V). Identical circumstances are given in pictures VII and VIII for a stage I and a stage II teratoma, respectively (100×). European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 8 CD105 and CD34 microvessel density depending on intensity of ets-1 expression. European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)

Fig. 9 Distribution of tumor stage depending on microvessel density determined by CD105. European Urology 2003 44, 329-336DOI: (10.1016/S0302-2838(03)00262-8)