Rakesh K. Goyal, Kelong Han, Donna A. Wall, Michael A

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Presentation transcript:

Sirolimus Pharmacokinetics in Early Postmyeloablative Pediatric Blood and Marrow Transplantation  Rakesh K. Goyal, Kelong Han, Donna A. Wall, Michael A. Pulsipher, Nancy Bunin, Stephan A. Grupp, Sripal R. Mada, Raman Venkataramanan  Biology of Blood and Marrow Transplantation  Volume 19, Issue 4, Pages 569-575 (April 2013) DOI: 10.1016/j.bbmt.2012.12.015 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Whole-blood 0 h concentrations of sirolimus for all subjects (n = 40) over a dosing interval, individually for each patient (left) and in 4 groups (right): no fluconazole, concomitant i.v. fluconazole, concomitant oral fluconazole, and vomiting after sirolimus administration. Biology of Blood and Marrow Transplantation 2013 19, 569-575DOI: (10.1016/j.bbmt.2012.12.015) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Standard box-and-whisker plots showing Cl/F, Vd/F, and t1/2 of sirolimus in the ≤12-year and >12-year age groups. Solid horizontal lines represent median values. Biology of Blood and Marrow Transplantation 2013 19, 569-575DOI: (10.1016/j.bbmt.2012.12.015) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Standard box-and-whisker plots showing sirolimus trough concentrations and AUC0-24 in Caucasian and Hispanic patients. Solid horizontal lines represent median values. Biology of Blood and Marrow Transplantation 2013 19, 569-575DOI: (10.1016/j.bbmt.2012.12.015) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Standard box-and-whisker plots showing dose-normalized trough sirolimus concentrations (C0 and C24) in patients receiving concomitant fluconazole therapy and those not receiving fluconazole. Values are median and 95% CI. Solid horizontal lines represent median values. Biology of Blood and Marrow Transplantation 2013 19, 569-575DOI: (10.1016/j.bbmt.2012.12.015) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions