Effect of rituximab on human in vivo antibody immune responses

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Presentation transcript:

Effect of rituximab on human in vivo antibody immune responses Mark D. Pescovitz, MD, Troy R. Torgerson, MD, PhD, Hans D. Ochs, MD, Dr Med, Elizabeth Ocheltree, BS, Paula McGee, MS, Heidi Krause-Steinrauf, MS, John M. Lachin, ScD, Jennifer Canniff, BS, Carla Greenbaum, MD, Kevan C. Herold, MD, Jay S. Skyler, MD, Adriana Weinberg, MD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 6, Pages 1295-1302.e5 (December 2011) DOI: 10.1016/j.jaci.2011.08.008 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Mean titers (and 95% confidence limits) for measles (A), mumps (B), rubella (C), tetanus (D), diphtheria (E), and hepatitis A (F) from a repeated-measures model with adjustments for baseline titer (except for hepatitis A because its baseline titer was not measured), age, and sex. Two-sided unadjusted P values are reported. Log transformation of antigen titer was used for all but mumps. Log values were transformed to normal scale for the figure. Journal of Allergy and Clinical Immunology 2011 128, 1295-1302.e5DOI: (10.1016/j.jaci.2011.08.008) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Antibody response to phiX174 immunization over time in rituximab-treated and placebo-treated subjects and healthy control subjects (gray hatched area). Immunization times are indicated by arrows. Time 0 is before rituximab treatment. Healthy control subjects were only immunized 3 times. Geometric means were calculated by using natural logarithms and transformed back by means of exponentiation. P values are from a repeated-measures model. Journal of Allergy and Clinical Immunology 2011 128, 1295-1302.e5DOI: (10.1016/j.jaci.2011.08.008) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Individual antibody responses (ln[Kv]) to phiX174 immunization over time in rituximab-treated subjects. Journal of Allergy and Clinical Immunology 2011 128, 1295-1302.e5DOI: (10.1016/j.jaci.2011.08.008) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions