MDM Oct 2017 Agenda Medical Directors MEETING October 19-20 2017

Agenda – Day 1 Medical Directors’ Meeting Time Topic Presenter(s) Minutes Chair 09:00 – 09:15 Welcome, introductions and agenda Linn, Anthony, Lisa 15’ 09:15 – 09:45 Orphan drugs, avacopan and the Advocate trial Dieter, Peter 30’ Linn 09:45 - 10:15 Medical Update - What have we achieved in 2017? Thierry, Slava, Alain 10:15 – 10:30 Morning Coffee 10:30 – 11:00 Executive Update – Role of medical in the success of the business Chris, David Anthony 11:00 -12:30 Veltassa Update Open session: Collaboration Fabio, Thierry S, Claudio, Peter, Alain, Ansgar, Michael, Julie 90’ Lisa 12:30 – 13:15 Lunch 45’ 13:15 – 14:15 Velphoro and Renal Anaemia Update Sebastian, Sandra 60’ 14:15 Working Afternoon Tea 14:15 – 15:45 Centre of Excellence – Ask the expert - Market Place Donald, Katharina/Erol, Garth, Susanna/Linn, Gyde/Fernando Anthony, Lisa 15:45 – 15:50 Summary and close Thierry, Slava 5’ 16:30 – 22:00 GROUP ACTIVITY AND DINNER Theme: Working together….. Veltassa - Need to be interactive. Facilitator to focus on what does HQ need from affiliates and vice versa. Ad Boards/IITs/RCTs/Congress support. 25 November 2018

Agenda – Day 2 (VIFOR, OM, relypsa) Medical Directors’ Meeting Time Topic Presenter(s) Minutes Chair 09:30 – 10:00 OM Update Lorenz 30’ Anthony 10:00 – 10:30 Copyright Sangeetha Linn 10:30 -11:00 Morning coffee 11:00 -12:30 Ferinject Update Q&A session: HQ and affiliate interaction Fabio, Lennart, Garth, Gail Thierry 75’ 12:30 – 13:30 Lunch 13:30 – 14:15 Intravenous Iron Differentiation Scientific Repository Susanna, Beat, Michael, Lennart 45’ 14:15 – 14:45 EFFECT-HF Update Prof. Dirk van Veldhuisen 14:45 – 15:00 Open session 15’ 15:00 – 15:15 Closing remarks and end of meeting

Agenda – Day 2 (VFMCRP) Medical Directors’ Meeting Time Topic Presenter(s) Minutes Chair 08:30 – 08:45 Objectives and Intro 2nd day Slava, Lisa 15` Lisa 08:45 – 09:45 IV Iron Medical Plans 2018 IV Iron Best Practice Share Sandra, Christina TBD 30’ 09:45 – 10:45 Velphoro Medical Plans 2018 Velphoro Best Practice Share Sebastian, Chiara 10:45 -11:00 Break 15’ 11:00 – 12:00 Veltassa Medical Plans 2018 Veltassa Best Practice Share Thierry, Georgie, Lorrain 12:00 – 12:30 Portfolio view: resources, prioritization, need for support Discussion All Lisa, Slava 12:30 – 13:30 Lunch 60` 13:30 – 14:15 Intravenous Iron Differentiation Scientific Repository (joint session) Susanna, Beat, Michael, Lennart 45’ Anthony 14:15 – 14:45 New kids on the block: Rayaldee , Avacopan update Slava, David, Julian 14:45 – 15:30 Compliance update Kirsten 15:30 – 15:45 Summary and adjourn Slava, All