Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation Hani Harb, MSc, Diana Raedler, PhD, Nikolaus Ballenberger,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

What drives prescription patterns in pediatric asthma management?

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Clarification concerning amoxicillin skin testing

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Fatty acids, inflammation, and asthma

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma Diana Raedler, PhD, Nikolaus Ballenberger, PhD, Elisabeth Klucker,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Is 9 more than 2 also in allergic airway inflammation?

Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial Marko Kalliomäki, MD, PhD,

Desensitization to Chemotherapeutic Agents

Fatty acids, inflammation, and asthma

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

The National Biome Initiative: An allergy perspective

A network-based analysis of the late-phase reaction of the skin

Nonadherence to Asthma Treatment: Getting Unstuck

Peter M. Wolfgram, MD, David B. Allen, MD

Update on epigenetics in allergic disease

Etiology of asthma exacerbations

An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1– related disease in children Kumud K. Singh, PhD, Alexis Lieser, MD,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Penicillin Skin Testing Is a Safe and Effective Tool for Evaluating Penicillin Allergy in the Pediatric Population Stephanie J. Fox, MD, Miguel A. Park,

Reply Journal of Allergy and Clinical Immunology

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think Martin L. Moore, PhD, R.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

What is an “eosinophilic phenotype” of asthma?

Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD

Cephalosporin Side Chain Cross-reactivity

Medication use in children with asthma in Finland from 1995 to 2006

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Diagnosis and management of early asthma in preschool-aged children

Geographic variability in childhood asthma prevalence in Chicago

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

One step forward, 2 steps back: The enigma of preschool wheeze

Risk of oral food challenges

Acid-suppressive drug use in pregnancy and the toddler's asthma risk: A crossover, case-control study Bianca Mulder, BSc, Catharina Carolina Maria Schuiling-Veninga,

Measles and immunomodulation

The Editors' Choice Journal of Allergy and Clinical Immunology

The Editors' Choice Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress Edith Chen, PhD, Margaret D. Hanson, MA, Laurel.

Asthma: The past, future, environment, and costs

Genetic regulation of IgE responses: Achilles and the tortoise

Environmental factors and eosinophilic esophagitis

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Advances in pediatric asthma in 2007

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood Adnan Custovic, MD, PhD, Lars Soderstrom,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Brian F. Leas, MS, MA, Kristen E. D'Anci, PhD, Andrea J

Presentation transcript:

Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation Hani Harb, MSc, Diana Raedler, PhD, Nikolaus Ballenberger, PhD, Andreas Böck, PhD, Dörthe A. Kesper, PhD, Harald Renz, MD, Bianca Schaub, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 1, Pages 200-202 (July 2015) DOI: 10.1016/j.jaci.2015.01.027 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Histone acetylation at both H3 and H4 histones. A, Histone acetylation for TH1 genes IFNG and TBX21 showing no difference between HC children and children with AA. B, Histone acetylation for TH2 genes IL4, IL5, and IL13 showing a significant increase in histone acetylation at histone H3 at the IL13 locus in parallel with a trend for increased H4 acetylation in children with AA compared with HC children. C, Histone acetylation for FOXP3 showing a trend for increased H3 acetylation in children with AA compared with HC children; data presented as mean ± SE; n(HCs) = 18, n(AA) = 14; P value from Kruskal-Wallis test (IL13 H3/H4) or Tobit regression analysis (FOXP3 H3). *P < .05. Journal of Allergy and Clinical Immunology 2015 136, 200-202DOI: (10.1016/j.jaci.2015.01.027) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions