Figure 5 Two approaches to therapeutic genome editing Figure 5 | Two approaches to therapeutic genome editing. a | In one approach, the genome-editing tools would be delivered directly into the body so that the genome editing can take place at the desired site in the genomes within the desired tissues in vivo. b | In another approach, the genome editing would take place ex vivo in patient-derived stem cells, which after editing could then be transplanted back into the patient or, more likely, differentiated into the desired tissue type and then transplanted. Strong, A. & Musunuru, K. (2016) Genome editing in cardiovascular diseases Nat. Rev. Cardiol. doi:10.1038/nrcardio.2016.139