The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis—a prospective multi-centre.

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

O. Dauwalder, L. Landrieve, F. Laurent, M. de Montclos, F

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

A. Bergman, D. Heimer, N. Kondori, H. Enroth

Symptomatic cytomegalovirus gastrointestinal infection with positive quantitative real- time PCR findings in apparently immunocompetent patients: a case.

The agony of choice in dermatophyte diagnostics—performance of different molecular tests and culture in the detection of Trichophyton rubrum and Trichophyton.

L. Boyanova Clinical Microbiology and Infection

Hospitalization in double-occupancy rooms and the risk of hospital-acquired influenza: a prospective cohort study E. Munier-Marion, T. Bénet, C. Régis,

Rapid and sensitive diagnosis of Toxoplasma gondii infections by PCR

Detection of fungal DNA in lysis–centrifugation blood culture for the diagnosis of invasive candidiasis in neonatal patients L. Trovato, P. Betta, M.G.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a revolution in clinical microbial identification A. Bizzini, G. Greub

I.J. Schalk Clinical Microbiology and Infection

Hospitalization in double-occupancy rooms and the risk of hospital-acquired influenza: a prospective cohort study E. Munier-Marion, T. Bénet, C. Régis,

Approach to diagnosis of infective endocarditis

Incidence and outcome of Staphylococcus aureus endocarditis—a 10-year single-centre northern European experience H. Asgeirsson, A. Thalme, M. Kristjansson,

D. Khalil, M. Hultin, M.U. Rashid, B. Lund

Control of multidrug-resistant Gram-negative bacteria in low- and middle-income countries—high impact interventions without much resources N. Singh,

Association of vancomycin serum concentrations with efficacy in patients with MRSA infections: a systematic review and meta-analysis T. Steinmetz, N.

Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications T.-L. Liao, Y.-M.

Migrant health—a cause for concern?

E. Bronska, J. Kalmusova, O. Dzupova, V. Maresova, P. Kriz, J. Benes

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

A. Ignacio, M. R. Fernandes, V. A. A. Rodrigues, F. C. Groppo, A. L

A. F. Simonetti, C. Garcia-Vidal, D. Viasus, D. García-Somoza, J

E. Cambau, M. Drancourt Clinical Microbiology and Infection

Chlamydia trachomatis infections in heterosexuals attending sexually transmitted disease clinics in Slovenia D. Kese, M. Maticic, M. Potocnik Clinical.

V.E. Nambudiri, R.C. Dwyer, C.A. Camargo, T.S. Kupper, D.J. Pallin

Detection of microorganisms in blood specimens using matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a review M. Drancourt

Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008–2013 L.E.B. Nabarro, R.A. Lever, M. Armstrong,

Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice? T. Coenye, D. Goeres, F. Van Bambeke, T. Bjarnsholt

Trends in length of stay, mortality and readmission among patients with community- acquired bacteraemia M. Søgaard, R.W. Thomsen, R.B. Bang, H.C. Schønheyder,

Vector control: a cornerstone in the malaria elimination campaign

Comparison of respiratory virus shedding by conventional and molecular testing methods in patients with haematological malignancy L. Richardson, J. Brite,

Switch to oral antibiotics in the treatment of infective endocarditis is not associated with increased risk of mortality in non–severely ill patients

Polymerase-chain reaction/electrospray ionization-mass spectrometry for the detection of bacteria and fungi in bronchoalveolar lavage fluids: a prospective.

F. Bittar, J.-M. Rolain Clinical Microbiology and Infection

The occurrence of Legionella species other than Legionella pneumophila in clinical and environmental samples in Denmark identified by mip gene sequencing.

Corticosteroids for the treatment of human infection with influenza virus: a systematic review and meta-analysis J.-W. Yang, L.-C. Fan, X.-Y. Miao, B.

S. Imbert, J.-Y. Brossas, M. Palous, I. Joly, I. Meyer, A. Fekkar

Metagenomics and probiotics

Gender differences in treatment outcomes of tuberculosis patients in Taiwan: a prospective observational study J.-Y. Feng, S.-F. Huang, W.-Y. Ting, Y.-C.

Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma

Impact of rapid microbial identification directly from positive blood cultures using matrix- assisted laser desorption/ionization time-of-flight mass spectrometry.

T.M. File Clinical Microbiology and Infection

Systematic review of antibiotic consumption in acute care hospitals

Advantages and limitations of genomics in prokaryotic taxonomy

H. M. El Sahly, L.D. Teeter, J.M. Musser, E.A. Graviss

M. Bassetti, M.P. Molinari, M. Mussap, C. Viscoli, E. Righi

Sequential time to positivity of blood cultures can be a predictor of prognosis of patients with persistent Staphylococcus aureus bacteraemia M.-S. Hsu,

Molecular identification of Acinetobacter sp

Dynamics of hepatitis B virus quasispecies heterogeneity in association with nucleos(t)ide analogue treatment determined by MALDI-TOF MS M. Rybicka,

Correlation between time to positivity of blood cultures with clinical presentation and outcomes in patients with Klebsiella pneumoniae bacteraemia: prospective.

An after-hours clinical liaison blood culture service—is it worth it?

Increasing numbers of hospitalizations and deaths with mention of Clostridium difficile infection, north-eastern Italy, 2008–2013 U. Fedeli, E. Schievano,

Statin use and clinical outcomes among pneumonia patients

Initial use of combination treatment does not impact survival of 106 patients with haematologic malignancies and mucormycosis: a propensity score analysis

Survival of rhinoviruses on human fingers

O. Dauwalder, L. Landrieve, F. Laurent, M. de Montclos, F

Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre R.R. Laffer, P. Graber, P.E. Ochsner, W. Zimmerli

Virology: a scientific discipline facing new challenges

Modelling during an emergency: the 2009 H1N1 influenza pandemic

R. Khatib, G. Simeunovic, M. Sharma, M. G. Fakih, L. B. Johnson, L

Association between hypoalbuminemia and mortality among subjects treated with ertapenem versus other carbapenems: prospective cohort study O. Zusman,

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

Bloodstream infections as a marker of community-acquired sepsis severity. Results from the Portuguese community-acquired sepsis study (SACiUCI study)

Impact of antibiotic restrictions: the patient's perspective

CMI readers' survey Clinical Microbiology and Infection

Rajko Saletinger, Mario Poljak, Franc Strle

The future of diagnostic bacteriology

Presentation transcript:

The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis—a prospective multi-centre European observational study M.J. O’Dwyer, M.H. Starczewska, J. Schrenzel, K. Zacharowski, D.J. Ecker, R. Sampath, D. Brealey, M. Singer, N. Libert, M. Wilks, J.-L. Vincent Clinical Microbiology and Infection Volume 23, Issue 3, Pages 208.e1-208.e6 (March 2017) DOI: 10.1016/j.cmi.2016.11.010 Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Twenty-eight-day mortality. Among those patients with a negative blood culture result, those with a positive PCR/ESI-MS test result have a higher mortality. A McNemar’s test was performed on the non-surviving patients, which indicated that the total number of positive tests for each method was statistically different (McNemar test statistic=45, degree of freedom=1 and p <0.0001). BC, blood culture; PCR/ESI-MS, PCR followed by electrospray ionization-mass spectrometry. Clinical Microbiology and Infection 2017 23, 208.e1-208.e6DOI: (10.1016/j.cmi.2016.11.010) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions