Defining an extended-spectrum β-lactamase

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Presentation transcript:

Defining an extended-spectrum β-lactamase D.M. Livermore Clinical Microbiology and Infection Volume 14, Pages 3-10 (January 2008) DOI: 10.1111/j.1469-0691.2007.01857.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Structure of an oxyimino-aminothiazolyl cephalosporin. The C=N–OR group, shaded, is held rigid and shields the β-lactam ring from attack by classic β-lactamases, but not by extended-spectrum β-lactamases. Cefuroxime, cefotaxime, ceftriaxone, ceftazidime, cefepime and cefpirome are all designed on this scaffold. Clinical Microbiology and Infection 2008 14, 3-10DOI: (10.1111/j.1469-0691.2007.01857.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions