Sitosterolemia: platelets on high-sterol diet by Hervé Falet Blood Volume 122(15):2534-2535 October 10, 2013 ©2013 by American Society of Hematology

Impaired ABCG5/ABCG8 heterodimer function in Abcg5−/− or Abcg8−/− hepatocytes and enterocytes leads to increased plasma sterol levels. Impaired ABCG5/ABCG8 heterodimer function in Abcg5−/− or Abcg8−/− hepatocytes and enterocytes leads to increased plasma sterol levels. Sterols accumulate in the platelet membrane, resulting in calpain activation, reduced αIIbβ3 surface expression, loss of the GPIbα-FlnA linkage, microparticle formation, and poor hemostatic functions. Hervé Falet Blood 2013;122:2534-2535 ©2013 by American Society of Hematology