Dose-Response Relationship Between Severe Hypercholesterolemia and Body Mass Index in Healthy Young Adults Tomohide Yamada, MD, PhD, Shintaro Yanagimoto,

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Presentation transcript:

Dose-Response Relationship Between Severe Hypercholesterolemia and Body Mass Index in Healthy Young Adults Tomohide Yamada, MD, PhD, Shintaro Yanagimoto, MD, PhD, Takashi Kadowaki, MD, PhD Mayo Clinic Proceedings Volume 92, Issue 7, Pages 1167-1168 (July 2017) DOI: 10.1016/j.mayocp.2017.05.007 Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Dose-response relationship between body mass index and various cutoff values of low-density lipoprotein cholesterol (LDL-C) level in healthy young adults. Multiple logistic regression analysis was employed to determine the odds ratio (OR) and 95% CI for associations between elevation of LDL-C level and body mass index, adjusted for systolic blood pressure and age. We used Stata statistical software, version 14.0 (StataCorp) to evaluate potential nonlinear relationships, applying cubic splines with 4 knots in set percentiles (5%, 35%, 65%, and 95%). Mayo Clinic Proceedings 2017 92, 1167-1168DOI: (10.1016/j.mayocp.2017.05.007) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions