Rem uniquely inhibits CaV1

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Rem uniquely inhibits CaV1 Rem uniquely inhibits CaV1.2 using both β-binding–dependent and β-binding–independent mechanisms. Rem uniquely inhibits CaV1.2 using both β-binding–dependent and β-binding–independent mechanisms. (A) Exemplar CaV1.2 Ba2+ currents elicited from HEK293 cells expressing α1C + β2a ± Rem (columns 1 and 2) or α1C + β2a,TM ± Rem (columns 3 and 4). Ba2+ currents were elicited by 25-ms test pulse depolarizations (from −50 to +100 mV in 10-mV increments) from a holding potential of −90 mV. (B) Population bar charts showing the impact of Rem on peak IBa from channels reconstituted with either α1C + β2a (Left) or α1C + β2a,TM (Right). *P < 0.01, Student’s unpaired t test. (C and D) Data for CaV1.3 channels reconstituted with either α1D + β2a ± Rem or α1D + β2a,TM ± Rem, same format as A and B. (E and F) Data for CaV2.1 channels reconstituted with either α1A + β2a ± Rem or α1A + β2a,TM ± Rem, same format as A and B. (G and H) Data for CaV2.2 channels reconstituted with either α1B + β2a ± Rem or α1B + β2a,TM ± Rem, same format as A and B. Data are means ± SEM. Akil A. Puckerin et al. PNAS 2018;115:47:12051-12056 ©2018 by National Academy of Sciences