Uric Acid: A Clearer Focus

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Presentation transcript:

Uric Acid: A Clearer Focus Jerry Yee, MD Advances in Chronic Kidney Disease Volume 19, Issue 6, Pages 353-355 (November 2012) DOI: 10.1053/j.ackd.2012.09.001 Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Proposed model of uric acid/urate pathophysiology in humans. Abbreviations: GFR, glomerular filtration rate; GLUT9, glucose-like transporter 9; HFCS, high fructose corn syrup; HTN, hypertension; NO, nitric oxide; RAS, renin-angiotensin system; REN, renin gene; ROS, reactive oxygen species; UMOD, uromodulin gene; URAT1, uric acid transporter-1. Diagram by Pablo Buitrón de la Vega, with iMindmap v. 6.0, ThinkBuzan, Cardiff. Advances in Chronic Kidney Disease 2012 19, 353-355DOI: (10.1053/j.ackd.2012.09.001) Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 The nephrologist focuses sharply on the constellations of uric acid/urate, in order to resolve this entity's physiology and pathophysiology. Illustration by Tom Mattix, Mattix Illustration. Advances in Chronic Kidney Disease 2012 19, 353-355DOI: (10.1053/j.ackd.2012.09.001) Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions