LC unit recordings in unrestrained narcoleptic dogs

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Presentation transcript:

LC unit recordings in unrestrained narcoleptic dogs AQ CG IC 2 msec 25 µV BC R7 5M BC 5MET R3 Wu, Gulyani et al. 1999 Unit Hipp EMG EOG EEG nonREM REM 5 sec QW LC unit recordings in unrestrained narcoleptic dogs

A B C D LC unit recordings in unrestrained narcoleptic dogs EOG EMG Hipp Units Cataplexy onset 4 sec Cataplexy offset Time (sec) 1 spikes/bin Mean 30 Amplitude (mV) 20 -20 A B C D Wu, Gulyani et al. 1999 LC unit recordings in unrestrained narcoleptic dogs

Locus coeruleus (noradrenergic) Dorsal raphe (serotonergic) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 Locus coeruleus (noradrenergic) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Dorsal raphe (serotonergic) Discharge rate (Hz) 7 Tuberomammillary (histaminergic) 6 5 4 3 2 1 John, Wu, Boehmer, Siegel, Neuron 2004 AW QW SWS REM CAT

Locus coeruleus (noradrenergic) Dorsal raphe (serotonergic) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 Locus coeruleus (noradrenergic) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Dorsal raphe (serotonergic) Discharge rate (Hz) 7 Tuberomammillary (histaminergic) 6 5 4 3 2 1 John, Wu, Boehmer, Siegel, Neuron 2004 AW QW SWS REM CAT

John, Wu, Boehmer, Siegel, Neuron 2004

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