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Presentation transcript:

(vary time, physiological state, disease, ...) Detection Quantity 1 2 3 Protein ... 1 2 3...104 Gene Repeat (vary time, physiological state, disease, ...) Information Cells Extraction DNA and proteins * Chemical Processing Label and amplification Biological Engineering

Silicon Biology Challenges Signal transduction Extraction DNA and proteins Cells Silicon Biology Challenges Signal transduction Solid – liquid interface ... Quantity 1 2 3...104 Gene Quantity 1 2 3 Protein

Electronic detection of DNA hybridization DNA probe sequence Am DNA probe sequence A DNA target sequence cA surface potential active surface depletion region DNA hybridization Silicon Glass *Fabricated by Emily Cooper at MIT’s MTL *Assay developed by Dr. Juergen Fritz