Understanding Statin Metabolism
Patients Most at Risk For Statin-Drug Interactions
Common Drug Classes That May Interact With Statins
Basics of Statin Metabolism
What Happens to Statins in the Body?*
Hydrophilic vs Lipophilic Statins
"First Pass" Metabolism
"First Pass" Metabolism (cont)
"First Pass" Metabolism (cont)
Molecular Structure of Statins
Statin Drug Properties Overview
Selected Drug Interactions That Increase Statin Levels
Statin-Associated Myopathy Risk Factors
Statin Dosing Considerations
Simvastatin Label Change Due to Drug Interactions
Gender Differences in Response to Statins
Racial Differences in Response to Statins
INTREPID Trial Statin Therapy in HIV Patients
INTREPID Trial Results
REPRIEVE Trial
REPRIEVE Trial Hypotheses
Why Pitavastatin?
Statin Dose Adjustment Based on Renal Function
Intensity of Statin Therapy
Statin-Associated Muscle Symptoms vs Statin Intolerance
Management of Statin-Related AEs
Clinical Management of the Patient
Conclusion
Abbreviations
Abbreviations (cont)
Abbreviations (cont)