Comparison of the model incorporating daily dose to that incorporating Cmax. Comparison of the model incorporating daily dose to that incorporating Cmax.

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Comparison of the model incorporating daily dose to that incorporating Cmax. Comparison of the model incorporating daily dose to that incorporating Cmax. (A) AUCs and 95% confidence intervals are depicted for the ROC curves derived from the models incorporating either daily dose or Cmax. The covariates are listed on the left, and the AUC for each one is shown on the right next to the 95% confidence interval (shown in brackets). (B) The ROC curves for the model incorporating daily dose and Cmax are indicated by red and blue lines, respectively. The 95% confidence intervals for the model incorporating daily dose and Cmax are shaded red or blue, respectively. Overlap between the confidence intervals for the two ROC curves appears in violet. Ashley R. Maiuri et al. J Pharmacol Exp Ther 2017;362:459-473 Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics