Energy Sparing Orexigenic Inflammation of Obesity

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Energy Sparing Orexigenic Inflammation of Obesity Aileen Lee, Vishwa Deep Dixit Cell Metabolism Volume 26, Issue 1, Pages 10-12 (July 2017) DOI: 10.1016/j.cmet.2017.06.013 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Microglia-Mediated Hypothalamic Inflammation in Obesity During dietary nutrient excess, NF-κB-mediated activation of long-lived residential microglia recruits bone-marrow-derived myeloid cells that adopt a microglial phenotype. Forced activation of NF-κB signaling in residential microglia by ablation of A20 recruits myeloid-derived microglia and suppresses neuronal responsiveness to metabolic hormones, such as leptin, to regulate food intake and energy expenditure and affect obesity susceptibility. ANS, autonomic nervous system; BAT, brown adipose tissue. Cell Metabolism 2017 26, 10-12DOI: (10.1016/j.cmet.2017.06.013) Copyright © 2017 Elsevier Inc. Terms and Conditions