Muscular Contractions

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Presentation transcript:

Muscular Contractions Contracting and Relaxing Skeletal Muscle

Anatomy of a Muscle Fiber (Cell) Sarcolemma Myofibril Sarcomere Z line

Anatomy of a Sarcomere Actin Myosin

Contraction Overview Lovely artwork courtesy of David Goodsell and the RCSB Protein Data Bank

Steps of a Muscle Contraction Nerve causes release of acetylcholine (ACh)

Steps of a Muscle Contraction Reception of ACh causes an action potential (electrical nerve signal) in muscle cell

Steps of a Muscle Contraction Action potential causes release of calcium in muscle cell Meanwhile…

Steps of a Muscle Contraction Calcium binds, forming troponin complex and revealing myosin binding sites.

Steps of a Muscle Contraction Sliding filament theory

Contraction Overview Lovely artwork courtesy of David Goodsell and the RCSB Protein Data Bank

Relaxation Acetylcholinesterase breaks down Ach Active transport prepares the muscle cell for future action potentials Active transport removes free calcium from muscle cells ATP breaks actin-myosin linkage

Relaxation

Interference Botox & botulism – block acetylcholine release Rigor mortis – can’t keep calcium out of cells so muscles contract, lack of ATP prevents myosin from releasing actin