Serum IgG (A–D) and IgA (E–H) titer from BALB/c mice (n = 5/group) at day 0 or following COBRA P1 virus i.n., i.p., or i.m. prime at day 21 or following.

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Serum IgG (A–D) and IgA (E–H) titer from BALB/c mice (n = 5/group) at day 0 or following COBRA P1 virus i.n., i.p., or i.m. prime at day 21 or following the i.p. or i.m. boost at day 42 against the homologous COBRA P1 rHA Ag. For IgG titer, sera were tested at 1:500, whereas for IgA at 1:50. Serum IgG (A–D) and IgA (E–H) titer from BALB/c mice (n = 5/group) at day 0 or following COBRA P1 virus i.n., i.p., or i.m. prime at day 21 or following the i.p. or i.m. boost at day 42 against the homologous COBRA P1 rHA Ag. For IgG titer, sera were tested at 1:500, whereas for IgA at 1:50. Shown results are expressed as absolute mean values plus SEM obtained in a single experiment and using the different mouse group sera. Data are representative of two independent experiments evaluating serum IgG and IgA reactivity of the same mouse groups against the COBRA P1 rHA Ag. For each independent experiment, mouse sera were run in duplicate. ***p < 0.001, *p ≤ 0.05. Giuseppe A. Sautto et al. ImmunoHorizons 2018;2:226-237 Copyright © 2018 The Authors