The mechanisms that regulate systemic resilience in humans and animals

Slides:

Advertisements

Similar presentations

Skin temperature, tactile processing, and vividness of the illusion Moseley G L et al. PNAS 2008;105: ©2008 by National Academy of Sciences.

Advertisements

Comparison (θ) of the mean dinucleotide variability distribution for (A) genes with MAE vs. Comparison (θ) of the mean dinucleotide variability distribution.

Comparison (R) of the mean observed to expected dinucleotide distribution for (A) genes with MAE vs. Comparison (R) of the mean observed to expected dinucleotide.

Age-to-age infection rate matrices and age-specific infection and incidence rates forecasted in 2050 for India and Ethiopia, from the full model (Left.

Does the effect of staying in school until age 16 depend on the BMI PGS? Bars show 2SLS point estimates of effect of staying in school until age 16 on.

(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.

Schematic representation of possible effects of different factors on systemic resilience. Schematic representation of possible effects of different factors.

The evolution of WCI for biological specificity makes organisms more evolvable. The evolution of WCI for biological specificity makes organisms more evolvable.

(A) Schematic diagram of TGC

The prevalence of diabetes (A), impaired glucose tolerance (B), impaired fasting glucose (C), and impaired glucose metabolism (D) among those with Finnish.

Deep neural networks (DNNs) can successfully identify, count, and describe animals in camera-trap images. Deep neural networks (DNNs) can successfully.

Components of the yield trend.

Motor coordination is enhanced by genetic deletion of Best1 or MAOB but impaired by overexpression of MAOB. (A) Experimental timeline and schematic illustration.

Structure-based ligand design toward a selective M3R antagonist.

Principal component analysis of the GO category composition of all genes in each genome/transcriptome and WGD paralogs. Principal component analysis of.

Variance priming for spatially nonoverlapping prime–target pairs.

Social activity of humans and bots over time.

WCI evolve as organisms become more complex.

A model for dual inhibition of BCL2 and MCL1 to release BIM and induce apoptosis. A model for dual inhibition of BCL2 and MCL1 to release BIM and induce.

Estimation of R(t). Estimation of R(t). (A) Daily R(t) as inferred from the daily incidence of new infections for one stochastic model realization. Tg.

Exploratory behavior in the light/dark box before the 4-wk protocol (Pre) was comparable among groups. Exploratory behavior in the light/dark box before.

Object exploration times before (Pre) and after (Post) the 4-wk protocol. Object exploration times before (Pre) and after (Post) the 4-wk protocol. During.

LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. LRP1-deleted mice have a stunted phenotype.

Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation.

Admixture modeling of Altai populations and the Khövsgöl main cluster using qpAdm. Admixture modeling of Altai populations and the Khövsgöl main cluster.

Outline of the problem and experimental approach.

Variance priming. Variance priming. (A) Mean RTs for both levels of prime variance (x axis; high or low) and both levels of target variance (lines; high.

Transcriptional response to mating in whole A. gambiae females.

Metabolic effects of K107R and rosiglitazone treatment.

Comparison between conventional wide-field detection and multifocus detection. Comparison between conventional wide-field detection and multifocus detection.

Extracellular GABA level is decreased by genetic deletion of Best1 or MAOB but increased by overexpression of MAOB. (A) Schematic illustration for microdialysis.

Light-activated RPS6 phosphorylation depends on auxin but not photosynthesis or exogenous glucose. Light-activated RPS6 phosphorylation depends on auxin.

Bivariate density representation of the joint posterior distributions for the number of demes and the germination rate (b). Bivariate density representation.

Statistical evaluation of demographic scenarios indicated by the posterior probability for each model. Statistical evaluation of demographic scenarios.

Distinct TF motifs are associated with decreased or increased H3K27 acetylation peaks in hypothyroidism. Distinct TF motifs are associated with decreased.

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

Effect of the temperature-sensitive mutation hsp90G17OD on the activity of the c-src regulatory kinase Csk and on the maturation of c-srcK295M at the semirestrictive.

Dependence of DesII steady-state parameters V (●) and (○) on pH.

(A) Communication fluxes PS(T|r′) conditional to the rank r′ for dataset D3. (A) Communication fluxes PS(T|r′) conditional to the rank r′ for dataset D3.

Catherine M. Pound et al. Hospital Pediatrics 2017;7:

Rotational and vibrational energy distributions of surface scattered molecules. Rotational and vibrational energy distributions of surface scattered molecules.

Pyoverdine production measured as RFUs standardized by OD significantly decreases with length of infection in years. Pyoverdine production measured as.

Sarcomere length-dependence of the M3 reflection at rest (A) and at the plateau of an isometric tetanus (B). Sarcomere length-dependence of the M3 reflection.

Snapshots of the population evolving antibiotic resistance.

Peptide release is not impacted by phosphorothioate modification at interface of the P-site and A-site codons. Peptide release is not impacted by phosphorothioate.

Phase diagrams from experiments for (A) and (B) metronome(s) per swing and from numerical simulations with metronomes (C) with metronome frequency f vs.

Coutilization of glucose–xylose mixtures by batch fermentations.

NsiR4 is involved in regulating NH4+ assimilation.

Schematic representation of our random walk model with environmental state-dependent dynamics. Schematic representation of our random walk model with environmental.

Consequences of a resistance cost or a finite growth rate below the staircase. Consequences of a resistance cost or a finite growth rate below the staircase.

Spiral wave initiation due to a FPR in a 2D medium.

Chimeras emerge with intermediate spring rate κ in a “competition” zone between two fully synchronous modes. Chimeras emerge with intermediate spring rate.

Snapshots of equilibrated structures of PrPC.

Simultaneous observation of two dynamic caged rotators with equal (A) and opposite (B) handedness; images recorded with a time lap of 340 s (VB = -2.07 V,

Median and likely range (17th–83rd percentile as used in the AR5) estimates of the ice sheet SLR contributions for different temperature scenarios and.

Proposed model of the tumor-suppressive effects of TPL2 in the lung.

Example of the spontaneous plastic event exhibiting a concatenation of a series of Eshelby quadrupoles resulting in a correlated displacement field with.

Coupled folding equilibrium describing the shift toward denatured material upon interaction with the cellular interior, as formalized in Eqs. 3–5. Coupled.

(A–F) FRET provides evidence for compaction.

The closed squares show the cumulative percentage of fisheries that collapsed in the Gulf of Mexico between 1950 and 2001 based upon the criterion used.

Mediation model of study 4.

(A and B) Fourier transform spectra obtained at different temperatures and excitation fluences in B1g (A, 1.91 eV probing energy) and A1g + B2g (B, 2.45.

Effect of pH and bicarbonate (HCO3) vs

Steep decline of heterozygosity (based on 100-bp windows), Tajima’s D values on a chromosomal arm 2R region (8,700,000–8,820,000) in D. simulans (A), and.

Correlation between Ti→jS(r) and Ti→jM(r) for pair of locations (gray dots) separated by a distance of (A) r=1 km, (B) r=5 km, (C) r=20 km, (D) r=50 km,

Flux distributions for different rank and distance groups.

Interpass temperature

Temporal behavior of mismatch between fully renewable electricity production and demand in Switzerland throughout the year for the urban scenario (red)

Map of sites with ages and postulated early and later pathways associated with modern humans dispersing across Asia during the Late Pleistocene. Map of.

© The Author(s) Published by Science and Education Publishing.

Presentation transcript:

The mechanisms that regulate systemic resilience in humans and animals. The mechanisms that regulate systemic resilience in humans and animals. The resilience of the whole depends on the resilience of subsystems that regulate vital parameters such as temperature, glucose level, and mood. Those in turn depend, among other things, upon the functional reserves (overcapacity) of organs that inevitably wear down with aging, depending on stressors, lifestyle, and genetic make-up. Marten Scheffer et al. PNAS 2018;115:47:11883-11890 ©2018 by National Academy of Sciences