Martin J. Bishop, Edward Vigmond, Gernot Plank Biophysical Journal

Slides:

Advertisements

Similar presentations

Analysis of Kinetic Intermediates in Single-Particle Dwell-Time Distributions Daniel L. Floyd, Stephen C. Harrison, Antoine M. van Oijen Biophysical Journal.

Advertisements

Counter-Intuitive Stochastic Behavior of Simple Gene Circuits with Negative Feedback Tatiana T. Marquez-Lago, Jörg Stelling Biophysical Journal Volume.

X-Ray Absorption Spectroscopy of Dinuclear Metallohydrolases David L. Tierney, Gerhard Schenk Biophysical Journal Volume 107, Issue 6, Pages

A Hydrodynamic Model for Hindered Diffusion of Proteins and Micelles in Hydrogels Ronald J. Phillips Biophysical Journal Volume 79, Issue 6, Pages

Cross-Correlated TIRF/AFM Reveals Asymmetric Distribution of Force-Generating Heads along Self-Assembled, “Synthetic” Myosin Filaments André E.X. Brown,

Lever-Arm Mechanics of Processive Myosins Yujie Sun, Yale E. Goldman Biophysical Journal Volume 101, Issue 1, Pages 1-11 (July 2011) DOI: /j.bpj

The Importance of the Hook Region of the Cochlea for Bone-Conduction Hearing Namkeun Kim, Charles R. Steele, Sunil Puria Biophysical Journal Volume 107,

The Interrelations among Stochastic Pacing, Stability, and Memory in the Heart Hila Dvir, Sharon Zlochiver Biophysical Journal Volume 107, Issue 4, Pages.

Nonlinear Poisson Equation for Heterogeneous Media Langhua Hu, Guo-Wei Wei Biophysical Journal Volume 103, Issue 4, Pages (August 2012) DOI: /j.bpj

Thomas A. Csepe, BSc, Brian J. Hansen, BSc, Vadim V. Fedorov, PhD

Maryam Sayadi, Seiichiro Tanizaki, Michael Feig Biophysical Journal

Volume 7, Issue 1, Pages (January 2010)

Volume 99, Issue 10, Pages (November 2010)

Multi-Image Colocalization and Its Statistical Significance

Peng Du, Gregory O'Grady, Leo K. Cheng, Andrew J. Pullan

Monitoring the Structural Behavior of Troponin and Myoplasmic Free Ca2+ Concentration during Twitch of Frog Skeletal Muscle Tatsuhito Matsuo, Hiroyuki.

Volume 99, Issue 10, Pages (November 2010)

Volume 102, Issue 5, Pages (March 2012)

One-Dimensional Mathematical Model of the Atrioventricular Node Including Atrio- Nodal, Nodal, and Nodal-His Cells S. Inada, J.C. Hancox, H. Zhang, M.R.

Volume 100, Issue 12, Pages (June 2011)

Investigating How Peptide Length and a Pathogenic Mutation Modify the Structural Ensemble of Amyloid Beta Monomer Yu-Shan Lin, Gregory R. Bowman, Kyle A.

A Model of H-NS Mediated Compaction of Bacterial DNA

The Transfer Functions of Cardiac Tissue during Stochastic Pacing

Composition Fluctuations in Lipid Bilayers

Susanne Karsch, Deqing Kong, Jörg Großhans, Andreas Janshoff

Mechanism for Triggered Waves in Atrial Myocytes

Joseph V. Tranquillo, Nima Badie, Craig S. Henriquez, Nenad Bursac

David A. Vorp, PhD, M.L. Raghavan, BS, Marshall W. Webster, MD

Volume 96, Issue 4, Pages (February 2009)

Volume 13, Issue 1, Pages (January 2016)

Theoretical and Computational Investigation of Flagellin Translocation and Bacterial Flagellum Growth David E. Tanner, Wen Ma, Zhongzhou Chen, Klaus.

Lyme disease and cardiac sarcoidosis: Management of associated ventricular arrhythmias Jorge Romero, MD, FHRS, Ulrich Jorde, MD, Juan Carlos Diaz, MD,

Volume 95, Issue 2, Pages (July 2008)

Volume 101, Issue 2, Pages (July 2011)

Veniamin Y. Sidorov, Marcella C. Woods, John P. Wikswo

Dynamic Origin of Spatially Discordant Alternans in Cardiac Tissue

Noise Underlies Switching Behavior of the Bacterial Flagellum

Volume 102, Issue 1, Pages (January 2012)

S. Majid Hosseini, James J. Feng Biophysical Journal

Alexander J. Sodt, Richard W. Pastor Biophysical Journal

Volume 101, Issue 11, Pages (December 2011)

Volume 111, Issue 12, Pages (December 2016)

Drift and Behavior of E. coli Cells

The “Mirror” Estimate: An Intuitive Predictor of Membrane Polarization during Extracellular Stimulation Sébastien Joucla, Blaise Yvert Biophysical Journal

Stochastic Pacing Inhibits Spatially Discordant Cardiac Alternans

Bidirectional Power Stroke by Ncd Kinesin

Polymorphic ventricular arrhythmia triggered by temporary epicardial right ventricular stimulation after cardiac surgery Carlos Lopez, MD, Teresa Oloriz,

Caroline Mendonca Costa, PhD

Volume 107, Issue 9, Pages (November 2014)

Volume 97, Issue 12, Pages (December 2009)

Adam Sokolow, Yusuke Toyama, Daniel P. Kiehart, Glenn S. Edwards

Multi-Image Colocalization and Its Statistical Significance

Radiofrequency ablation of ventricular tachycardia originating from a lipomatous hamartoma localized in the right ventricle cavity Jin Xu, PhD, Yingmin.

Hyper-response to cardiac resynchronization with permanent His bundle pacing: Is parahisian pacing sufficient? Olujimi A. Ajijola, MD, PhD, Jorge Romero,

Nothing inside the heart – Combining epicardial pacing with the S-ICD

Long-Range Nonanomalous Diffusion of Quantum Dot-Labeled Aquaporin-1 Water Channels in the Cell Plasma Membrane Jonathan M. Crane, A.S. Verkman Biophysical.

Toward a Consensus View of Duplex RNA Flexibility

Stochastic Pacing Inhibits Spatially Discordant Cardiac Alternans

Evaluating Intramural Virtual Electrodes in the Myocardial Wedge Preparation: Simulations of Experimental Conditions G. Plank, A. Prassl, E. Hofer, N.A.

Peng Du, Gregory O'Grady, Leo K. Cheng, Andrew J. Pullan

Volume 107, Issue 3, Pages (August 2014)

Volume 88, Issue 6, Pages (June 2005)

Enrique M. De La Cruz, Jean-Louis Martiel, Laurent Blanchoin

Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems

Volume 104, Issue 4, Pages (February 2013)

Volume 111, Issue 2, Pages (July 2016)

A Model of H-NS Mediated Compaction of Bacterial DNA

Volume 112, Issue 9, Pages (May 2017)

Fangqiang Zhu, Klaus Schulten Biophysical Journal

Volume 98, Issue 3, Pages (February 2010)

Presentation transcript:

Cardiac Bidomain Bath-Loading Effects during Arrhythmias: Interaction with Anatomical Heterogeneity Martin J. Bishop, Edward Vigmond, Gernot Plank Biophysical Journal Volume 101, Issue 12, Pages 2871-2881 (December 2011) DOI: 10.1016/j.bpj.2011.10.052 Copyright © 2011 Biophysical Society Terms and Conditions

Figure 1 Effects of bath-loading during pacing in the slab model without transmural fiber rotation. Vm distributions for BDMNB (left) and BDM (right), 50 ms following pacing stimulus along the x = 0 (top) and y = 3 cm (bottom) planes. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions

Figure 2 Effects of bath-loading during arrhythmias in the slab model without transmural fiber rotation. (a) Vm distributions (top row) and filaments shown (bottom row) for the BDM (top panel) and BDMNB (bottom panel) cases for time instances 50–350 ms following arrhythmia induction. Right panel shows an example of wavebreak in both models. Variation in total number of individual filaments present in each ms of the simulation (b) and total mean filament length (c) over the duration of the arrhythmia episodes for the BDM (red) and BDMNB (blue) cases. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions

Figure 3 Effects of bath-loading during pacing in the slab model with transmural fiber rotation. Vm distributions for BDMNB (left) and BDM (right), 50 ms following pacing stimulus along the x = 0 (top) and y = 3 cm (bottom) planes. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions

Figure 4 Effects of bath-loading during arrhythmias in the slab model with fiber rotation. (a) Vm distributions (top row) and filaments shown (bottom row) for BDM (top panel) and BDMNB (bottom panel) cases for time instances 50–300 ms following arrhythmia induction. Variation in total number of individual filaments present in each ms of the simulation (a) and total mean filament length (b) over the duration of the arrhythmia episodes for the BDM (solid) and BDMNB (dashed) cases. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions

Figure 5 Effects of bath-loading during pacing in the whole-ventricular model. Vm distributions following pacing shown for BDMNB (left) and BDM (right) cases, for apical (top) and transmural (bottom) stimulation. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions

Figure 6 (a) Histograms showing durations of arrhythmias within the whole ventricular model where post-shock behavior is computed using the BDM (top) and BDMNB (bottom) approaches. (b) Premature termination of arrhythmia in whole-ventricular model with BDM approach. Vm distributions within the volume of the ventricles at certain instances in time following the attempted induction of an arrhythmia with CI = 195 ms in the BDM (top panel) and BDMNB (bottom panel) cases. For each panel, posterior epicardial views (top row), as well as views taken with an axial slice to expose anterior endocardial surfaces and septum (bottom row), are shown. White curved arrows show rotation direction of induced arrhythmia. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions

Figure 7 (a) Comparison of sustained episodes of arrhythmia in ventricular model with BDM and BDMNB approaches. Vm distributions and filament locations within the ventricular volume at certain times following arrhythmia induction with CI = 180 ms in the BDM (left panel) and BDMNB (right panel) cases. For each panel, posterior epicardial views (top row), and longitudinal slices to expose anterior endocardial surfaces/septum (center row), are shown, with filament locations identified (bottom row). Variation in total number of filaments present in each ms of the simulation (b) and total mean filament length (c) over the duration of arrhythmia episodes for BDM (solid) and BDMNB (dashed) cases within the ventricular model for CI = 180. Biophysical Journal 2011 101, 2871-2881DOI: (10.1016/j.bpj.2011.10.052) Copyright © 2011 Biophysical Society Terms and Conditions