Act1, Scene Brain: Astrocytes Play a Lead Role

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Presentation transcript:

Act1, Scene Brain: Astrocytes Play a Lead Role Jane M. Rodgers, Liang Zhou, Stephen D. Miller Immunity Volume 32, Issue 3, Pages 302-304 (March 2010) DOI: 10.1016/j.immuni.2010.03.009 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 IL-17-Stimulated, Act1-Dependent Stimulation of CNS Astrocytes Is Required for Progression of EAE via Chemokine-Mediated Recruitment of Peripheral Inflammatory Cells Kang et al. (2010) suggest a necessary role for astrocytes in EAE pathology. After activated myelin-specific Th17 cells infiltrate the CNS and are restimulated to produce IL-17, astrocytes that respond via expression of IL-17R are stimulated to produce leukocyte-attracting chemokines in an Act1-dependent manner. Astrocyte-derived chemokines then recruit a second wave of peripheral inflammatory cells, which mediate EAE progression via Th17 cell-mediated bystander demyelination. Immunity 2010 32, 302-304DOI: (10.1016/j.immuni.2010.03.009) Copyright © 2010 Elsevier Inc. Terms and Conditions