Copyright, Disease Management Strategy Group, 2012 A SYSTEMS APPROACH TO DISEASE MANAGEMENT IS ONE IN WHICH INTERACTING ANALYTICAL TOOLS AND PROGRAMS ARE COMBINED INTO A SEAMLESS PROCESS RESULTING IN THE BEST OUTCOMES POSSIBLE WITH A GIVEN APPLICATION OF RESOURCES. Copyright, Disease Management Strategy Group, 2012

Systems Approach Disease Management Results Individual Level Quantify Disease Incidence by Type/Division/Sex/Age/Region Wellcast ROI Gather Risk Factor Data Client Vendor Results Corporate Level Develop List of Potential Prevention Programs Internal/External Prioritize Diseases Based on Cost and Incidence Quantify Medical & Economic Costs by Disease Wellcast ROI Perform Simulations to Determine and Rank ROI’s Vary Price/Participation/Success Rates Wellcast ROI Select and Obtain Approval of Programs Based on ROI Develop Implementation Plan Target Communication Resource Allocation Perform ROI Variance Analyses Re-administer HRA Clinical Outcomes Wellcast ROI Implement Programs at Individual Level Copyright, Disease Management Strategy Group, 2016

Step 1 Gather Risk Factor Data Administer HRA Questionnaires Copyright, Disease Management Strategy Group, 2016

Quantify Disease Incidence by Age, Gender, Region and Function Step 2 Quantify Disease Incidence by Age, Gender, Region and Function Wellcast ROI Copyright, Disease Management Strategy Group, 2016

Quantify Disease Costs by Age, Gender, Region and Function Step 3 Quantify Disease Costs by Age, Gender, Region and Function Wellcast ROI Productivity Losses Retraining Costs Replacement Costs Relocation Costs Disability Costs Copyright, Disease Management Strategy Group, 2016

Copyright, Disease Management Strategy Group, 2016 Step 4 Prioritize Diseases Based on Costs by Age, Gender, Region and Function Wellcast ROI Copyright, Disease Management Strategy Group, 2016

Step 5 Develop List of Interventions by Disease CHD Exercise Diet Management Stress Management Smoking Cessation Blood Pressure Medication Cholesterol Medication Copyright, Disease Management Strategy Group, 2016

Copyright, Disease Management Strategy Group, 2016 Step 6 Run ROI Simulations with Cost/Participation/Success Assumptions Wellcast ROI CHD Program Cost Reduction Risk Factors Exercise $100 BP/Chol/Smoking Diet Management $ 75 BP/Chol Stress Management $ 50 BP/Smoking Blood Pressure Medication $150 BP Cholesterol Medication $120 Chol Smoking Cessation $ 60 BP/Smoking Copyright, Disease Management Strategy Group, 2016

Program Effectiveness CHD Exercise Copyright, Disease Management Strategy Group, 2016

Step 7 Rank & Select Programs Based on ROI Wellcast ROI Copyright, Disease Management Strategy Group, 2016

Step 8 Develop Implementation Plan Target & Communication Wellcast (groups with greatest benefit) Resource Allocation Wellcast (based on NPV and IRR) Copyright, Disease Management Strategy Group, 2016

Copyright, Disease Management Strategy Group, 2016 Step 9 Conduct Variance Analyses (after Re-Administering HRA’s) Wellcast ROI Risk Factor Goal Actual Variance ROI Systolic BP -8 -7 -4% Diastolic BP -10 -12 +8% HDL +7 +9 +10% LDL -4 -3 -1% Smoking -3 -5 +25% Copyright, Disease Management Strategy Group, 2016