Histomorphology in a case of mixed (cellular and humoral) acute kidney allograft rejection (patient 10). Histomorphology in a case of mixed (cellular and.

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MONOCYTE/MACROPHAGES AND C4d IN RENAL ALLOGRAFTS Alex Magil, MD.

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Presentation transcript:

Histomorphology in a case of mixed (cellular and humoral) acute kidney allograft rejection (patient 10). Histomorphology in a case of mixed (cellular and humoral) acute kidney allograft rejection (patient 10). First biopsy performed 15 d after renal transplantation with (A) granulocytes in peritubular capillaries (PTC; indicated by arrows) (periodic acid—Schiff [PAS]), (B) signs of vascular (indicated by arrows) and interstitial rejection (PAS), and (C) endothelial C4d deposition in PTC (immunohistochemistry on a paraffin section). Follow-up biopsy performed 32 d after transplantation without signs of cellular rejection and disappearance of peritubular granulocytes (D) (PAS), but (E) persistence of C4d staining (immunohistochemistry on a paraffin section). Magnifications: ×650 in A; ×250 in B and D; ×400 in C and E. GEORG A. BÖHMIG et al. JASN 2001;12:2482-2489 ©2001 by American Society of Nephrology