Schematic representation of possible effects of different factors on systemic resilience. Schematic representation of possible effects of different factors.

Slides:

Advertisements

Similar presentations

Figure 1.1 The observer in the truck sees the ball move in a vertical path when thrown upward. (b) The Earth observer views the path of the ball as a parabola.

Advertisements

Structures of nonnative SOD1 oligomers revealed by EM

Comparison (θ) of the mean dinucleotide variability distribution for (A) genes with MAE vs. Comparison (θ) of the mean dinucleotide variability distribution.

Comparison (R) of the mean observed to expected dinucleotide distribution for (A) genes with MAE vs. Comparison (R) of the mean observed to expected dinucleotide.

Balancing selection characterizes both MAE genes and cell type-specific genes (expressed in either nsc or asl but not in both). Balancing selection characterizes.

Does the effect of staying in school until age 16 depend on the BMI PGS? Bars show 2SLS point estimates of effect of staying in school until age 16 on.

(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.

Empirical mutation-selection phase diagram of tumor evolution.

Model structure. Model structure. (A) Visualization of the multiplex network representing a subsample of 10,000 individuals of the synthetic population.

The mechanisms that regulate systemic resilience in humans and animals

The evolution of WCI for biological specificity makes organisms more evolvable. The evolution of WCI for biological specificity makes organisms more evolvable.

Empirical mutation-selection phase diagram of tumor evolution.

Underlying mechanisms.

(A) Schematic diagram of TGC

Schematic of elephant ivory showing longitudinal cross-section of a tusk with pulp cavity, dentine, and cementum. Schematic of elephant ivory showing longitudinal.

Representation of the evolutionary model.

High-denisty DOT system.

Motor coordination is enhanced by genetic deletion of Best1 or MAOB but impaired by overexpression of MAOB. (A) Experimental timeline and schematic illustration.

Exercise and Risk of Breast Cancer

Variance priming for spatially nonoverlapping prime–target pairs.

WCI evolve as organisms become more complex.

Proposed reaction sequence initiating HMBPP reduction as it was derived from crystallographic data. Proposed reaction sequence initiating HMBPP reduction.

GPR124 promotes cell migration.

H3K4me3 pattern association with functionally relevant genes and changes over time. H3K4me3 pattern association with functionally relevant genes and changes.

Object exploration times before (Pre) and after (Post) the 4-wk protocol. Object exploration times before (Pre) and after (Post) the 4-wk protocol. During.

The genetic profile of LBA Khövsgöl individuals summarized by PCA and ADMIXTURE. (A) Khövsgöl (Kvs, ARS017, and ARS026) and other ancient individuals (colored.

Admixture modeling of Altai populations and the Khövsgöl main cluster using qpAdm. Admixture modeling of Altai populations and the Khövsgöl main cluster.

Competition binding assays.

Extracellular GABA level is decreased by genetic deletion of Best1 or MAOB but increased by overexpression of MAOB. (A) Schematic illustration for microdialysis.

Structures of natural cytotoxicity receptors.

WPV1 complete VP1 gene phylogeny including the RC2010 viruses.

(A) Schematic representation of kalata B1 showing the cyclic cystine knot, the amino acid sequence in single letter code, and the regions used for oligonucleotide.

Communication and jump size distance distributions.

Schematic representation describing the design of PPCs with Au NPs

Bivariate density representation of the joint posterior distributions for the number of demes and the germination rate (b). Bivariate density representation.

Distinct TF motifs are associated with decreased or increased H3K27 acetylation peaks in hypothyroidism. Distinct TF motifs are associated with decreased.

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

GT repeats are unique to Cdk6 and are conserved in different mammals.

Simulations and experiments demonstrating the existence of several intermediate regimes between the initial viscous regime and the final IV regime for.

(A) Communication fluxes PS(T|r′) conditional to the rank r′ for dataset D3. (A) Communication fluxes PS(T|r′) conditional to the rank r′ for dataset D3.

Catherine M. Pound et al. Hospital Pediatrics 2017;7:

Pyoverdine production measured as RFUs standardized by OD significantly decreases with length of infection in years. Pyoverdine production measured as.

Lymphocyte lineage trees produced by long-term live cell microscopy.

Sarcomere length-dependence of the M3 reflection at rest (A) and at the plateau of an isometric tetanus (B). Sarcomere length-dependence of the M3 reflection.

Separation by HPLC of lipopeptide adducts from the tryptic digest of involucrin. Separation by HPLC of lipopeptide adducts from the tryptic digest of involucrin.

UniFrac analysis at high time resolution.

Rescue of the sel-12 Egl phenotype by PS1 and PS1ΔE9 expressed from arrays formed at a concentration of 2 μg/ml. Rescue of the sel-12 Egl phenotype by.

Peptide release is not impacted by phosphorothioate modification at interface of the P-site and A-site codons. Peptide release is not impacted by phosphorothioate.

Identification of the AlkZ active site.

Clustering of residues for which PREs unaccounted for by the main state were measured. Clustering of residues for which PREs unaccounted for by the main.

Reduction or stabilization of TTR levels improves TTR-mediated locomotion impairments. Reduction or stabilization of TTR levels improves TTR-mediated locomotion.

Schematic representation of our random walk model with environmental state-dependent dynamics. Schematic representation of our random walk model with environmental.

Consequences of a resistance cost or a finite growth rate below the staircase. Consequences of a resistance cost or a finite growth rate below the staircase.

Chimeras emerge with intermediate spring rate κ in a “competition” zone between two fully synchronous modes. Chimeras emerge with intermediate spring rate.

Quantitative analysis of CR evolution through conditioning sessions for the four experimental groups. Quantitative analysis of CR evolution through conditioning.

Activation of PKR by the PBM decoy peptide.

Snapshots of equilibrated structures of PrPC.

Example of the spontaneous plastic event exhibiting a concatenation of a series of Eshelby quadrupoles resulting in a correlated displacement field with.

Mediation model of study 4.

(A and B) Fourier transform spectra obtained at different temperatures and excitation fluences in B1g (A, 1.91 eV probing energy) and A1g + B2g (B, 2.45.

Peel test of mucus–PCL adhesive strength.

Steep decline of heterozygosity (based on 100-bp windows), Tajima’s D values on a chromosomal arm 2R region (8,700,000–8,820,000) in D. simulans (A), and.

LMP1 activates IRF7 through CTAR2.

Correlation between Ti→jS(r) and Ti→jM(r) for pair of locations (gray dots) separated by a distance of (A) r=1 km, (B) r=5 km, (C) r=20 km, (D) r=50 km,

Schematic diagram displaying the potential effects of climate-driven shifts in basin-scale atmospheric pressure gradients leading to the observed interannual.

Flux distributions for different rank and distance groups.

(A) Correlation between the shear modulus (Fig

(a) Pattern of UWHBs, represented as green segments joining paired α-carbons, for human Hb β-subunit. (a) Pattern of UWHBs, represented as green segments.

Disease severity and classification agreement between methods: schematic representation of the principle that classification agreement between two methods.

Schematic representation of the proposed definition of prolonged mechanical ventilation (PMV) in neonates and children. Schematic representation of the.

Presentation transcript:

Schematic representation of possible effects of different factors on systemic resilience. Schematic representation of possible effects of different factors on systemic resilience. While effects of some factors are only detrimental (A) or positive (C), the effect of other factors on resilience peaks at intermediate levels (B). Effects of aging on resilience (D) are moderated by the mechanisms summarized in Fig. 1. Marten Scheffer et al. PNAS 2018;115:47:11883-11890 ©2018 by National Academy of Sciences