by Andrew D. Redd, Ava Avalos, and Max Essex

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by Andrew D. Redd, Ava Avalos, and Max Essex Infection of hematopoietic progenitor cells by HIV-1 subtype C, and its association with anemia in southern Africa by Andrew D. Redd, Ava Avalos, and Max Essex Blood Volume 110(9):3143-3149 November 1, 2007 ©2007 by American Society of Hematology

Verification of HIV-1 infection of HPC-CFUs by Alu-LTR integration. Verification of HIV-1 infection of HPC-CFUs by Alu-LTR integration. (A) Infected colonies and blank wells were tested for integration using nested PCR.17 The resulting DNA product was approximately 150 bp in length. 8E5 cellular DNA (lanes 1-4: 50 000, 5000, 500, and 50 copies, respectively), a blank MJ4 well as the negative control (lane 5), MJ4-infected BFU-E colonies (lanes 6-8), MJ4-infected CFU-GM colonies (lanes 9-13), the MHX-infected CFU-GM colony (lane 14), BW-2036–infected BFU-E colonies (lanes 15, 16), BW-2036–infected CFU-GM colonies (lanes 17, 18), and H2O (lane 19) are shown. (B) Representative fluorescent curves of SYBR Green integration assay. Standards are indicated as copy number of 8E5 cellular DNA; positive colony types and negative blank wells from MJ4 and patient 13 are also shown with colors indicated in parentheses. Andrew D. Redd et al. Blood 2007;110:3143-3149 ©2007 by American Society of Hematology

Efficiency of single-colony infections using primary HIV-1 isolates. Efficiency of single-colony infections using primary HIV-1 isolates. Total colonies infected are shown as percentage of colonies tested. All colonies were compared with HXB2RU3CI for significance. Cloned virus isolates are shown (▨). The percentage of HIV-1C isolates that infect progenitor cells differs significantly from the percentage of HIV-1B as determined by Fisher exact test, P < .05. Andrew D. Redd et al. Blood 2007;110:3143-3149 ©2007 by American Society of Hematology