The evolution of WCI for biological specificity makes organisms more evolvable. The evolution of WCI for biological specificity makes organisms more evolvable.

Slides:

Advertisements

Similar presentations

BACKGROUND E. coli is a free living, gram negative bacterium which colonizes the lower gut of animals. Since it is a model organism, a lot of experimental.

Advertisements

 DNA Microarray. What is DNA Microarray?  DNA Microarray allows scientists to perform an experiment on thousands of genes at the same time.

Introduction to Biology. What is Biology? It is the study of life, living things, what they are, how they work, and how they interact with one another.

Comparison (θ) of the mean dinucleotide variability distribution for (A) genes with MAE vs. Comparison (θ) of the mean dinucleotide variability distribution.

Comparison (R) of the mean observed to expected dinucleotide distribution for (A) genes with MAE vs. Comparison (R) of the mean observed to expected dinucleotide.

(A) Schematic illustration of the experimental design for the analysis of the RNase activity of MARF1 in oocytes by mutating the conserved D272 residue.

Chronic stress accelerated DSS-induced colitis.

Balancing selection characterizes both MAE genes and cell type-specific genes (expressed in either nsc or asl but not in both). Balancing selection characterizes.

Age-to-age infection rate matrices and age-specific infection and incidence rates forecasted in 2050 for India and Ethiopia, from the full model (Left.

(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.

Scheme of the design of the anti-lysozyme Goldbody.

The plant respiratory chain supercomplex.

Distribution of mutations in different groups of genes, in cancer with extreme ML values. Distribution of mutations in different groups of genes, in cancer.

Empirical mutation-selection phase diagram of tumor evolution.

Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25 cells. Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25.

Schematic representation of possible effects of different factors on systemic resilience. Schematic representation of possible effects of different factors.

The inferred metabolism in Sulcia and Nasuia bacteriocytes.

Empirical mutation-selection phase diagram of tumor evolution.

Representation of the evolutionary model.

Distribution of mutations in different groups of genes, in cancer with extreme ML values. Distribution of mutations in different groups of genes, in cancer.

HDAC3, but not HDAC2 is in complex with tau protein.

Pretreatment of VSV-GPΔ to form VSV-GP19K rescues infection in the α5β1-integrin-negative CHO cells. Pretreatment of VSV-GPΔ to form VSV-GP19K rescues.

Components of the yield trend.

Energy diagrams and orientation distributions of the NO molecule.

Structure-based ligand design toward a selective M3R antagonist.

Principal component analysis of the GO category composition of all genes in each genome/transcriptome and WGD paralogs. Principal component analysis of.

Variance priming for spatially nonoverlapping prime–target pairs.

Social activity of humans and bots over time.

The repeat domain of Tau cross-links to α-tubulin.

WCI evolve as organisms become more complex.

Immunity-related genes and enhancers are enriched for eQTLs.

Estimation of R(t). Estimation of R(t). (A) Daily R(t) as inferred from the daily incidence of new infections for one stochastic model realization. Tg.

Evolution of Evolvability Complexity Club Alan N

Variance priming. Variance priming. (A) Mean RTs for both levels of prime variance (x axis; high or low) and both levels of target variance (lines; high.

Simulations capture the experimental force profiles for mutant I27 domains. Simulations capture the experimental force profiles for mutant I27 domains.

DSB induced by 5-OH-dCTP is generated during DNA repair via Nth.

Proposed schemes for OXT biosynthesis using the proteins encoded by the oxsA and oxsB production genes, which are annotated as an HD domain phosphohydrolase.

WPV1 complete VP1 gene phylogeny including the RC2010 viruses.

Combined LRTI prediction metric integrating pathogen detection and host gene expression. Combined LRTI prediction metric integrating pathogen detection.

Structural overview. Structural overview. (A) Domain organization of LRRK2. The residue boundary of the WD40 domain and locations of three recurrent disease.

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

Evolution of the global surface temperature of the last 22 ka: the reconstructions of M13 (1) (blue) after 11.3 ka and by Shakun et al. Evolution of the.

Mitofilin clusters are localized at the horizontal sides of mitochondria. Mitofilin clusters are localized at the horizontal sides of mitochondria. (A.

Effect of the temperature-sensitive mutation hsp90G17OD on the activity of the c-src regulatory kinase Csk and on the maturation of c-srcK295M at the semirestrictive.

(A) Communication fluxes PS(T|r′) conditional to the rank r′ for dataset D3. (A) Communication fluxes PS(T|r′) conditional to the rank r′ for dataset D3.

Catherine M. Pound et al. Hospital Pediatrics 2017;7:

Pyoverdine production measured as RFUs standardized by OD significantly decreases with length of infection in years. Pyoverdine production measured as.

Sarcomere length-dependence of the M3 reflection at rest (A) and at the plateau of an isometric tetanus (B). Sarcomere length-dependence of the M3 reflection.

Identification of candidate genes within the 1q32 locus.

Sequence conservation across the Ub-binding sites of human USPs

Excision of N7-methylguanine by AlkZ.

Peptide release is not impacted by phosphorothioate modification at interface of the P-site and A-site codons. Peptide release is not impacted by phosphorothioate.

NsiR4 expression is mediated through an NtcA-activated promoter.

Repertoire structure as relevant to vaccine response.

Nonsense and missense amino acid mutation analysis.

Structure of STAT6CF and N4 site DNA complex.

Crystal structure of STAT6CF-N3 complex and its comparison with STAT6CF-N4 complex structure. Crystal structure of STAT6CF-N3 complex and its comparison.

Landscape of genomic alterations in 444 tumors from 429 patients with mCRPC. Landscape of genomic alterations in 444 tumors from 429 patients with mCRPC.

Spiral wave initiation due to a FPR in a 2D medium.

Overview of the adaptive laboratory evolution experiment.

Dynamics of the model. Dynamics of the model. (A) Snapshot of a simulation. At this time, the population has adapted to the drug concentrations in compartments.

Tissue-specific transcriptome responses to fasting.

Performance of chronic METH-treated rats in the gambling test under the double-reward condition. Performance of chronic METH-treated rats in the gambling.

Mediation model of study 4.

Conceptual model of airflow-mediated mucus clearance from airways.

Correlation between Ti→jS(r) and Ti→jM(r) for pair of locations (gray dots) separated by a distance of (A) r=1 km, (B) r=5 km, (C) r=20 km, (D) r=50 km,

Flux distributions for different rank and distance groups.

(a) Pattern of UWHBs, represented as green segments joining paired α-carbons, for human Hb β-subunit. (a) Pattern of UWHBs, represented as green segments.

Temporal behavior of mismatch between fully renewable electricity production and demand in Switzerland throughout the year for the urban scenario (red)

Overview of the metabolism of S. aciditrophicus.

Presentation transcript:

The evolution of WCI for biological specificity makes organisms more evolvable. The evolution of WCI for biological specificity makes organisms more evolvable. (A) The response time for the organisms to evolve to function properly after a new task is introduced is shown as a function of the number of tasks (or complexity). Results are shown for both the full model and one wherein cooperative interactions between gene products is not allowed. (B) The number of mutations (which includes gene mutation, duplication, and loss) that the average organism needs to acquire to function properly after a new task is introduced is shown as a function of the number of tasks (or complexity). Results are shown for both the full model and one wherein cooperative interactions between gene products is not allowed. Ang Gao et al. PNAS 2018;115:47:E11053-E11060 ©2018 by National Academy of Sciences