Beyond the Patch Clamp: Nanotechnologies for Intracellular Recording

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Beyond the Patch Clamp: Nanotechnologies for Intracellular Recording Peter B. Kruskal, Zhe Jiang, Teng Gao, Charles M. Lieber Neuron Volume 86, Issue 1, Pages 21-24 (April 2015) DOI: 10.1016/j.neuron.2015.01.004 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Nanowires as a New Approach to Electrophysiology (A) New recording methods such as nanowires for localized intracellular recordings will have advantages compared to patch pipettes. Nanowire FETs require source (S) and drain (D) electrode connections for making high-sensitivity recordings. (B) 3D polymer probes can direct nanowires to neuronal processes or targeted cell types. (C) Nanowires may be integrated with 3D flexible electronics for experiments in cultures or, potentially, in vivo. Neuron 2015 86, 21-24DOI: (10.1016/j.neuron.2015.01.004) Copyright © 2015 Elsevier Inc. Terms and Conditions