Expression of insulin-like growth factor II mRNA-binding protein 3 predicts early recurrence and poor prognosis in intrahepatic cholangiocarcinoma Yu-Ling.

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Expression of insulin-like growth factor II mRNA-binding protein 3 predicts early recurrence and poor prognosis in intrahepatic cholangiocarcinoma Yu-Ling Chen, Yung-Ming Jeng, Hey-Chi Hsu, Hong-Shiee Lai, Po-Huang Lee, Po-Lin Lai, Ray-Hwang Yuan International Journal of Surgery Volume 11, Issue 1, Pages 85-91 (January 2013) DOI: 10.1016/j.ijsu.2012.11.021 Copyright © 2012 Surgical Associates Ltd Terms and Conditions

Fig. 1 Immunohistochemical study of insulin-like growth factor II mRNA-binding protein 3 (IMP3) protein expression in intrahepatic cholangiocarcinoma. IMP3 protein was not expressed in adjacent nontumorous tissue (A). The proportion of tumor cells positive for IMP3 immunostain varied considerably, ranging from ≤10% (B), 11–50% (C), to >50% (D). (A–D) × 400 (original magnification). International Journal of Surgery 2013 11, 85-91DOI: (10.1016/j.ijsu.2012.11.021) Copyright © 2012 Surgical Associates Ltd Terms and Conditions

Fig. 2 Kaplan–Meier survival curves for 61 patients with resected, unifocal, primary intrahepatic cholangiocarcinoma (ICC) in relation to the status of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression. Patients with IMP3-positive ICCs had significantly lower disease-free survival rate (p = 0.0001) (A) And overall survival rate (p = 0.0007) (B) Than those with IMP3-negative ICCs. (+), designated presence; (−), designated absence. International Journal of Surgery 2013 11, 85-91DOI: (10.1016/j.ijsu.2012.11.021) Copyright © 2012 Surgical Associates Ltd Terms and Conditions

Fig. 3 Kaplan–Meier survival curves for 61 patients with resected, unifocal, intrahepatic cholangiocarcinoma (ICC) in relation to presence or absence of early tumor recurrence (ETR). Patients with ETR had significantly lower disease-free survival rate (A) and overall survival rate (B) than those without ETR (p < 0.0001 and p = 0.0001, respectively). (+), designated presence; (−), designated absence. International Journal of Surgery 2013 11, 85-91DOI: (10.1016/j.ijsu.2012.11.021) Copyright © 2012 Surgical Associates Ltd Terms and Conditions

Fig. 4 Kaplan–Meier analysis of survival curves in 61 patients with or without insulin-like growth factor II mRNA-binding protein 3 (IMP3) expressed intrahepatic cholangiocarcinoma (ICC) in relation to tumor stage. The p value was from comparison of all four groups (log rank test). (A) High-stage ICC with concomitant IMP3 expression was associated with the worst disease-free survival (p < 0.0001). Interestingly, low-stage ICC with concomitant IMP3 expression also had significant worse disease-free survival than low-stage ICC without IMP3 expression (p = 0.0286). (B) High-stage ICC with concomitant IMP3 expression was associated with worst overall survival (p < 0.0001), significantly worse than ICC with high-stage tumor without IMP3 expression (p = 0.0245). (+), designated presence; (−), designated absence; L-stage, designated low-stage tumor; H-stage, designated high-stage tumor. International Journal of Surgery 2013 11, 85-91DOI: (10.1016/j.ijsu.2012.11.021) Copyright © 2012 Surgical Associates Ltd Terms and Conditions