Eric Niederhoffer SIU-SOM

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Presentation transcript:

Eric Niederhoffer SIU-SOM 11/27/2018 Olfaction Olfaction signaling Cyclic nucleotide gated channels Inositol trisphosphate/Ca2+/Protein kinase C Eric Niederhoffer SIU-SOM

Olfaction O BP OR AC Golfbg a GDP a GTP RK CNGC cAMP ATP CaM GTP GDP 11/27/2018 Olfaction O BP OR AC Golfbg a GDP a GTP RK CNGC cAMP ATP CaM GTP GDP 5’-AMP PDE Ca2+ ORi RK OR: odorant receptor O: odorant BP: binding protein Golf: G protein GDP: guanosine diphosphate GTP: guanosine triphosphate AC: adenylate cyclase ATP: adenosine triphosphate cAMP: cyclic adenosine monophosphate CNGC: cyclic nucleotide-gated channel CaM: calmodulin; decreases CNGC sensitivity PDE: phosphodiesterase 5’AMP: 5’-adenosine monophosphate RK: receptor kinase PLC: phospholipase C ER: endoplasmic reticulum PIP2: phosphatidylinositol-4,5-bisphosphate IP3: inositol-1,4,5-trisphosphate PKC: protein kinase C; increases sensitivity of AC and CNGC There appears to be a 3rd pathway that utilizes a guanylyl cyclase (cGMP) receptor. Odorant cells are one of the few cells where [Cl-] is greater inside than outside. -arrestin binds the phosphorylated receptor AND appears to recruit phosphodiesterase to degrade the cAMP signal Kallmann syndrome, a rare hypogonadotropic hypogonadism (IP3) Cl- Ca2+ GTP GDP Gq GDP GTP ER PKC OR PLC PIP2 O BP

Review Questions Which ions and ion channels are used for olfaction? 11/27/2018 Review Questions Which ions and ion channels are used for olfaction? Which signal transduction pathways are used for olfaction (enzymes, second messengers, receptors)?