A Molecular Code for Imprinting Drug-Cue Associations

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Presentation transcript:

A Molecular Code for Imprinting Drug-Cue Associations Adrian M. Gomez, Michael R. Bruchas Neuron Volume 96, Issue 1, Pages 3-5 (September 2017) DOI: 10.1016/j.neuron.2017.09.018 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Experimental Paradigm of HDAC5 Regulation of Cocaine Addiction-Related Behaviors in Nucleus Accumbens GABA Neurons Cocaine-induced phosphorylation mediates HDAC5 export to the cytoplasm and allows (green arrows) for cocaine-mediated gene transcription. Expression of a dephosphorylated form of HDAC5 induces nuclear import to negatively regulate (red bars) Npas4 and related genes implicated in cocaine-context learning. Neuron 2017 96, 3-5DOI: (10.1016/j.neuron.2017.09.018) Copyright © 2017 Elsevier Inc. Terms and Conditions