Miscellaneous Drugs Liquorice PH103.67

Department of Technical Education Andhra Pradesh Name : B.Sri Rama Murty Designation : Head of Pharmacy Section Branch : PHARMACY Institute : Govt.,Polytechnic for Women, Srikakulam Year/Semester : I Year Subject : Pharmacognosy Subject code : PH103 Topic : Miscellaneous Drugs Duration : 50 Mts Sub Topic : Liquorice Teaching Aids : PPT, Photographs PH103.67 ER-91/PH-103/1 of 5

Objectives On completion of this period you would be able to know about : The monograph of Liquorice PH103.67

Known to Unknown Have you ever heard the name “Atimadhuram”? Is it leaf or root? What is the official name of sweet root in the Pharamacognsy? PH103.67

Liquorice Synonym : Liquorice root, Glycyrrhiza, Mulethi Botanical Source: Dried peeled or unpeeled roots and stolons of the plant known as Glycyrrhiza glabra Family : Leguminosae Fig.67.1 Liquorice plant PH103.67 ER-91/PH-103/1 of 5

Liquorice Geographical source : Russia, Iran Italy, Spain Chaina, France Iraq and Greece Fig.67.2 Liquorice plant PH103.67

Liquorice Organoleptic characters: Color : Unpeeled - yellowish brown or dark brown Peeled - Yellow Odour : Faint and Characteristic Taste : Sweet Fig.67.3 Liquorice roots PH103.67

Liquorice Size : Length 20 to 50 cm. Diameter 2 cm. Shape : Cylindrical straight Peeled liquorice is angular Fracture : Fibrous in bark splintery in wood Fig.67.3 Liquorice roots PH103.67

Liquorice Chemical constituents: Triterpenoid saponin known as Glycyrrhizin (water soluble, 50 times sweeter than sucrose) Glycyrrhizin is a potassium and calcium salt of Glycyrrhizic acid PH103.67

Liquorice Chemical constituents : Glycyrrizic acid Glycyrrhetinic acid Other constituents : Flavone glycoside Glucose (upto 4%) Sucrose 2.5 to 6.5% Bitter principles Resins Asparagine (2 to 4%) and fat. Hydrolysis PH103.67

Liquorice Chemical tests : When moistened with 80% sulphuric acid liquorice develops a deep yellow color Due to change of flavone glycoside Liquiritin to Chalcone glycoside PH103.67

Liquorice USES : Demulcent Expectorant Sweetening agent Flavouring agent Antispasmodic PH103.67

Liquorice USES : Anti inflammatory Antiulcer In the treatment of Addison’s disease Also used in the preparation of cough lozenges Potentiate the laxative action of SennaS PH103.67

Summary In this class we learnt about : The Monograph Liquorice Glycyrrhiza glabra belongs to the family Leguminosae containsTriterpenoid saponin (Glycyrrhizin) is used as sweetening agent PH103.67

Quiz Botonical source of Liquorice is Glycyrrhiza glabra Glycyrrhiza sativum Glycyrrhiza purpurea Glycyrrhiza officinalis PH103.67

Quiz 2. Main chemical constituents present in Liquorice Alkaloids Volatile oil Glycosides Terpenoids PH103.67

Quiz 3. Liquorice is used as Spice Carminative Antibacterial Sweetening agent PH103.67

Frequently Asked Questions Write the uses and constituents of Liquorice Write the family and Biological source of Liquorice PH103.67